Annotations: 4RT4

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Dpy-30/Rlla-like	8104118	3001874	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Dpy-30/Rlla-like	8104118	3001874	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Dpy-30/Rlla-like	8104118	3001874	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Dpy-30/Rlla-like	8104118	3001874	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05186	e4rt4A1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: PF05186	ECOD (1.6)
B	PF05186	e4rt4B1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: PF05186	ECOD (1.6)
C	PF05186	e4rt4C1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: PF05186	ECOD (1.6)
D	PF05186	e4rt4D1	A: alpha duplicates or obligate multimers	X: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	H: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit (From Topology)	T: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit	F: PF05186	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
B	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
C	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)
D	1.20.890.10	Mainly Alpha	Up-down Bundle	cAMP-dependent Protein Kinase, Chain A	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF05186	Dpy-30 motif (Dpy-30)	Dpy-30 motif	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protein dpy-30 homolog	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	localization cellular localization transport establishment of localization in cell cellular process intracellular transport establishment of localization vesicle-mediated transport endosomal transport regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process localization cellular localization transport establishment of localization in cell cellular process intracellular transport establishment of localization vesicle-mediated transport endosomal transport regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biological process cellular metabolic process regulation of cellular metabolic process primary metabolic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization cellular component organization RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process protein-containing complex organization epigenetic regulation of gene expression biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cytoplasm protein-containing complex histone methyltransferase complex membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cytoplasm protein-containing complex histone methyltransferase complex catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen Set1C/COMPASS complex MLL1/2 complex MLL3/4 complex MLL1 complex
E	Peptide from COMPASS component BRE2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding	subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance nucleobase-containing compound metabolic process organic cyclic compound metabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle protein-containing complex Set1C/COMPASS complex histone methyltransferase complex catalytic complex membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen nucleoplasm organelle lumen methyltransferase complex nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037856	Sdc1/DPY30	Family
A, B, C, D	IPR007858	Dpy-30 motif	Conserved Site
A, B, C, D	IPR049629	DPY30/SDC1, dimerization/docking domain	Domain
E	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
E	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
E	IPR037353	Histone methyltransferase complex subunit ASH2	Family
E	IPR003877	SPRY domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9C005	androgenetic alopecia ovarian cancer breast cancer hereditary spastic paraplegia 4

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.