4RS4

Crystal structure and mutational analysis of the endoribonuclease from human coronavirus 229E

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4rs4b1	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
B	d4rs4b2	Alpha and beta proteins (a+b)	EndoU-like	EndoU-like	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
B	d4rs4b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
D	d4rs4d1	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
D	d4rs4d2	Alpha and beta proteins (a+b)	EndoU-like	EndoU-like	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
D	d4rs4d3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
E	d4rs4e1	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
E	d4rs4e2	Alpha and beta proteins (a+b)	EndoU-like	EndoU-like	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
E	d4rs4e3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
F	d4rs4f1	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
F	d4rs4f2	Alpha and beta proteins (a+b)	EndoU-like	EndoU-like	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
F	d4rs4f3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
A	d4rs4a1	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
A	d4rs4a2	Alpha and beta proteins (a+b)	EndoU-like	EndoU-like	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
A	d4rs4a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
C	d4rs4c1	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
C	d4rs4c2	Alpha and beta proteins (a+b)	EndoU-like	EndoU-like	automated matches	automated matches	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)
C	d4rs4c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HCoV-229E (Human coronavirus 229E ) [TaxId: 11137 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	XendoU_like	e4rs4B2	A: a+b complex topology	X: RNase A-like	H: EndoU-like (From Topology)	T: EndoU-like	F: XendoU_like	ECOD (1.6)
B	NSP11_2nd	e4rs4B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NSP11_2nd	ECOD (1.6)
D	XendoU_like	e4rs4D1	A: a+b complex topology	X: RNase A-like	H: EndoU-like (From Topology)	T: EndoU-like	F: XendoU_like	ECOD (1.6)
D	NSP11_2nd	e4rs4D2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NSP11_2nd	ECOD (1.6)
E	XendoU_like	e4rs4E1	A: a+b complex topology	X: RNase A-like	H: EndoU-like (From Topology)	T: EndoU-like	F: XendoU_like	ECOD (1.6)
E	NSP11_2nd	e4rs4E2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NSP11_2nd	ECOD (1.6)
F	XendoU_like	e4rs4F2	A: a+b complex topology	X: RNase A-like	H: EndoU-like (From Topology)	T: EndoU-like	F: XendoU_like	ECOD (1.6)
F	NSP11_2nd	e4rs4F1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NSP11_2nd	ECOD (1.6)
A	XendoU_like	e4rs4A1	A: a+b complex topology	X: RNase A-like	H: EndoU-like (From Topology)	T: EndoU-like	F: XendoU_like	ECOD (1.6)
A	NSP11_2nd	e4rs4A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NSP11_2nd	ECOD (1.6)
C	XendoU_like	e4rs4C1	A: a+b complex topology	X: RNase A-like	H: EndoU-like (From Topology)	T: EndoU-like	F: XendoU_like	ECOD (1.6)
C	NSP11_2nd	e4rs4C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: NSP11_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.160.820	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Nsp15 N-terminal domain-like	CATH (4.3.0)
B	3.40.50.11580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	nsp15 middle domain	CATH (4.3.0)
D	3.30.160.820	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Nsp15 N-terminal domain-like	CATH (4.3.0)
D	3.40.50.11580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	nsp15 middle domain	CATH (4.3.0)
E	3.30.160.820	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Nsp15 N-terminal domain-like	CATH (4.3.0)
E	3.40.50.11580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	nsp15 middle domain	CATH (4.3.0)
F	3.30.160.820	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Nsp15 N-terminal domain-like	CATH (4.3.0)
F	3.40.50.11580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	nsp15 middle domain	CATH (4.3.0)
A	3.30.160.820	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Nsp15 N-terminal domain-like	CATH (4.3.0)
A	3.40.50.11580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	nsp15 middle domain	CATH (4.3.0)
C	3.30.160.820	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Nsp15 N-terminal domain-like	CATH (4.3.0)
C	3.40.50.11580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	nsp15 middle domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF19215	Coronavirus replicase NSP15, uridylate-specific endoribonuclease (CoV_NSP15_C)	Coronavirus replicase NSP15, uridylate-specific endoribonuclease	This entry represents the C-terminal domain of coronavirus non-structural protein 15 (NSP15 or nsp15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain exhibits endoribonuclease activity designated ...	This entry represents the C-terminal domain of coronavirus non-structural protein 15 (NSP15 or nsp15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain exhibits endoribonuclease activity designated EndoU, highly conserved in all known CoVs and is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription [1, 2, 3]. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends [2, 3]. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) [3].	Domain
A, B, C, D, E A, B, C, D, E, F	PF19216	Coronavirus replicase NSP15, middle domain (CoV_NSP15_M)	Coronavirus replicase NSP15, middle domain	This entry represents the non-catalytic middle domain from coronavirus non-structural protein 15 (NSP15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain is formed by ten beta strands organised in ...	This entry represents the non-catalytic middle domain from coronavirus non-structural protein 15 (NSP15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain is formed by ten beta strands organised into three beta hairpins [1, 2].	Domain
A, B, C, D, E A, B, C, D, E, F	PF19219	Coronavirus replicase NSP15, N-terminal oligomerisation (CoV_NSP15_N)	Coronavirus replicase NSP15, N-terminal oligomerisation	This is the N-terminal domain of the coronavirus nonstructural protein 15 (NSP15), which is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. NSP15, is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) carryi ...	This is the N-terminal domain of the coronavirus nonstructural protein 15 (NSP15), which is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. NSP15, is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) carrying C-terminal catalytic domain belonging to the EndoU family. The SARS-CoV-2 NendoU monomers assemble into a double-ring hexamer, generated by a dimer of trimers. The hexamer is stabilized by the interactions of N-terminal oligomerization domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Uridylate-specific endoribonuclease	peptidase activity omega peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity 3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity peptidase activity omega peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity 3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding helicase activity RNA helicase activity ATP-dependent activity, acting on RNA ATP-dependent activity endonuclease activity RNA methyltransferase activity O-methyltransferase activity transferase activity, transferring one-carbon groups mRNA (nucleoside-2'-O-)-methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity methyltransferase activity mRNA methyltransferase activity 5'-3' RNA polymerase activity RNA polymerase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity lyase activity RNA binding nucleic acid binding ubiquitin-like protein peptidase activity cysteine-type deubiquitinase activity deubiquitinase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides cation binding transition metal ion binding zinc ion binding metal ion binding	cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral genome replication biosynthetic process cellular biosynthetic process cellular metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral genome replication biosynthetic process viral RNA genome replication organic cyclic compound biosynthetic process viral process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process viral gene expression viral protein processing gene expression DNA-templated transcription symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response response to host defenses response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus biological process involved in interaction with host symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity symbiont-mediated suppression of host signal transduction pathway modulation by symbiont of host process symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway catabolic process regulation of cellular process autophagy positive regulation of biological process modulation by virus of host process positive regulation of cellular metabolic process regulation of autophagy cellular catabolic process positive regulation of metabolic process induction by virus of host autophagy process utilizing autophagic mechanism positive regulation of cellular process modulation by virus of host cellular process positive regulation of autophagy regulation of biological process modulation by virus of host autophagy biological regulation regulation of cellular metabolic process regulation of catabolic process symbiont-mediated perturbation of host autophagy positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of metabolic process symbiont-mediated perturbation of host ubiquitin-like protein modification organonitrogen compound metabolic process proteolysis protein metabolic process	membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle host cell perinuclear region of cytoplasm host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR042515	Non-structural protein NSP15, N-terminal domain superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR048673	Nonstructural protein 13, stalk domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR046435	NSP14, guanine-N7-methyltransferase domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043174	Non-structural protein NSP15, middle domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR009469	RNA-dependent RNA polymerase, N-terminal, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043611	Coronavirus replicase NSP3, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR038123	Non-structural protein NSP4, C-terminal superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR047566	Coronavirus replicase NSP3, Y domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043178	Papain-like protease, thumb domain superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR046441	RNA-dependent RNA polymerase, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR048672	Nonstructural protein 13, zinc-binding domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043612	Non-structural protein NSP4, N-terminal, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044863	Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044343	Nonstructural protein 13, 1B domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR043608	Nonstructural protein 15, middle domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044353	NSP3, second ubiquitin-like (Ubl) domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037227	Endoribonuclease EndoU-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR027352	Nonstructural protein 13, zinc-binding domain, coronavirus-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013016	Peptidase C16, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037204	Non-structural protein NSP7 superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR047912	Non-structural protein 13, helicase domain, alphacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009466	Non-structural protein 14, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044357	NSP3, first ubiquitin-like (Ubl) domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR046436	Nidovirus 3'-5' exoribonuclease domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR046443	NSP1, globular domain, alpha/betacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR047570	NSP12, interface domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044313	Nonstructural protein 14, alphacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043610	Non-structural protein 6, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR027351	(+) RNA virus helicase core domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044322	Nonstructural protein 15, middle domain, alpha/betacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009461	Non-structural protein NSP16, coronavirus-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043477	Peptidase C30, domain 3, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018995	RNA synthesis protein NSP10, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043615	Nonstructural protein 2, N-terminal domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043606	Coronavirus replicase NSP15, N-terminal oligomerization	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044330	Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001205	RNA-directed RNA polymerase, C-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044401	NSP15, NendoU domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044369	Non-structural protein 6, alphacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR014822	Non-structural protein NSP9, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041679	DNA2/NAM7 helicase-like, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR037230	Non-structural protein NSP8 superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR044356	RNA-dependent RNA polymerase, alphacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR046440	Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR014828	Non-structural protein NSP7, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR032505	Non-structural protein NSP4, C-terminal, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR014829	Non-structural protein NSP8, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR046438	Nidovirus 2-O-methyltransferase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036499	Non-structural protein NSP9 superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR002589	Macro domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR008740	Peptidase C30, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036333	RNA synthesis protein NSP10 superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR047573	Non-structural protein 2, middle domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044309	Non-structural protein 5, alphacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043472	Macro domain-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR043609	NendoU domain, nidovirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044371	Non-structural protein 3, X-domain-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043613	Non-structural protein 2, C-terminal domain, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044385	Nonstructural protein 2, HCoV-229E-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain