4RAP

Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	hepto_Aah_TibC_1st	e4rapA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
A	Glyco_transf_9_C	e4rapA4	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
A	hepto_Aah_TibC_2nd	e4rapA3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
B	hepto_Aah_TibC_1st	e4rapB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
B	Glyco_transf_9_C	e4rapB3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
B	hepto_Aah_TibC_2nd	e4rapB1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
C	hepto_Aah_TibC_1st	e4rapC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
C	Glyco_transf_9_C	e4rapC3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
C	hepto_Aah_TibC_2nd	e4rapC1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
D	hepto_Aah_TibC_1st	e4rapD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
D	Glyco_transf_9_C	e4rapD3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
D	hepto_Aah_TibC_2nd	e4rapD1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
E	hepto_Aah_TibC_1st	e4rapE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
E	Glyco_transf_9_C	e4rapE3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
E	hepto_Aah_TibC_2nd	e4rapE2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
F	hepto_Aah_TibC_1st	e4rapF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
F	Glyco_transf_9_C	e4rapF4	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
F	hepto_Aah_TibC_2nd	e4rapF3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
G	hepto_Aah_TibC_1st	e4rapG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
G	Glyco_transf_9_C	e4rapG3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
G	hepto_Aah_TibC_2nd	e4rapG4	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
H	hepto_Aah_TibC_1st	e4rapH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
H	Glyco_transf_9_C	e4rapH3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
H	hepto_Aah_TibC_2nd	e4rapH1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
I	hepto_Aah_TibC_1st	e4rapI2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
I	Glyco_transf_9_C	e4rapI1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
I	hepto_Aah_TibC_2nd	e4rapI3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
J	hepto_Aah_TibC_1st	e4rapJ2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
J	Glyco_transf_9_C	e4rapJ4	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
J	hepto_Aah_TibC_2nd	e4rapJ3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
K	hepto_Aah_TibC_1st	e4rapK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
K	Glyco_transf_9_C	e4rapK1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
K	hepto_Aah_TibC_2nd	e4rapK3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)
L	hepto_Aah_TibC_1st	e4rapL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: hepto_Aah_TibC_1st	ECOD (1.6)
L	Glyco_transf_9_C	e4rapL3	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_9_C	ECOD (1.6)
L	hepto_Aah_TibC_2nd	e4rapL1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: hepto_Aah_TibC_2nd	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF01075	Glycosyltransferase family 9 (heptosyltransferase) (Glyco_transf_9)	Glycosyltransferase family 9 (heptosyltransferase)	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF21129	Glycosyltransferase TibC, N-terminal domain (TibC_1st)	Glycosyltransferase TibC, N-terminal domain	This domain is found at the N-terminal end of Glycosyltransferase TibC from Escherichia coli and similar bacterial. TibC is an autotransporter adhesin heptosyltransferase (AAH) homologue that catalyses the heptosylation of the autotransporters AIDA-I ...	This domain is found at the N-terminal end of Glycosyltransferase TibC from Escherichia coli and similar bacterial. TibC is an autotransporter adhesin heptosyltransferase (AAH) homologue that catalyses the heptosylation of the autotransporters AIDA-I/TibA and confers AIDA-I-mediated bacterial adhesion to host cells. This domain adopts a beta-barrel fold with two four-stranded sheets that pack against each other [1,2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Glycosyltransferase TibC	glycosyltransferase activity transferase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR049327	Autotransproter heptosyltransferase TibC/BAHTCr-like, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR030929	Glycosyltransferase Aah/TibC-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR002201	Glycosyl transferase, family 9	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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4RAP

Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage