Annotations: 4PQZ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21693	e4pqzA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: Nucleotidyltransferase substrate binding subunit/domain	F: PF21693	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21693	Transcriptional protein SWT1, C-terminal domain (SWT1_3rd)	Transcriptional protein SWT1, C-terminal domain	This domain is found at the C-terminal end of Transcriptional protein SWT1 from Saccharomyces cerevisiae and similar fungal proteins. SWT1 is an RNA endonuclease involved in quality control of nuclear messenger ribonucleoprotein particles (mRNPs). It ...	This domain is found at the C-terminal end of Transcriptional protein SWT1 from Saccharomyces cerevisiae and similar fungal proteins. SWT1 is an RNA endonuclease involved in quality control of nuclear messenger ribonucleoprotein particles (mRNPs). It consists of three domains: N-terminal, middle (Pfam:PF13638), and C-terminal domain (this entry). This domain shows three long antiparallel helices and three shorter helices. It shares characteristics with members of the HEPN domain (Pfam:PF05168) [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcriptional protein SWT1	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process nuclear mRNA surveillance of mRNP export organic substance biosynthetic process RNA catabolic process mRNA catabolic process nuclear RNA surveillance regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process nuclear mRNA surveillance of mRNP export organic substance biosynthetic process RNA catabolic process mRNA catabolic process nuclear RNA surveillance regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process catabolic process cellular biosynthetic process RNA metabolic process macromolecule catabolic process organic substance metabolic process negative regulation of cellular process RNA surveillance negative regulation of macromolecule metabolic process regulation of biosynthetic process nuclear-transcribed mRNA catabolic process nuclear mRNA surveillance biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002716	PIN domain	Domain
A	IPR049014	Transcriptional protein SWT1, C-terminal domain	Domain
A	IPR029060	PIN-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.