4OVZ
X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d4ovza2 | Alpha and beta proteins (a+b) | Cysteine proteinases | Cysteine proteinases | Papain-like viral protease catalytic domain | automated matches | (SARS coronavirus Urbani ) [TaxId: 228330 ], | SCOPe (2.08) |
A | d4ovza1 | Alpha and beta proteins (a+b) | beta-Grasp (ubiquitin-like) | Ubiquitin-like | automated matches | automated matches | (SARS coronavirus Urbani ) [TaxId: 228330 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Ubiquitin-like | 8091719 | 3000157 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Cysteine proteinases | 8091717 | 3001808 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Cysteine proteinases | 8091717 | 3001808 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | PLpro Zn-binding domain-like | 8091718 | 3002538 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Cysteine proteinases | 8091717 | 3001808 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Cysteine proteinases | 8091717 | 3001808 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | PLpro Zn-binding domain-like | 8091718 | 3002538 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF08715 | e4ovzA2 | A: a+b two layers | X: beta-Grasp | H: Ubiquitin-related | T: Ubiquitin-like | F: PF08715 | ECOD (1.6) |
A | PF08715 | e4ovzA1 | A: a+b complex topology | X: Cysteine proteinases-like | H: Cysteine proteinases (From Topology) | T: Cysteine proteinases | F: PF08715 | ECOD (1.6) |
B | PF08715 | e4ovzB1 | A: a+b complex topology | X: Cysteine proteinases-like | H: Cysteine proteinases (From Topology) | T: Cysteine proteinases | F: PF08715 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.10.20.540 | Alpha Beta | Roll | Ubiquitin-like (UB roll) | Papain-like viral protease, N-terminal domain | CATH (4.3.0) |
A | 1.10.8.1190 | Mainly Alpha | Orthogonal Bundle | Helicase, Ruva Protein | domain 3 | CATH (4.3.0) |
A | 2.60.120.1680 | Mainly Beta | Sandwich | Jelly Rolls | CATH (4.3.0) | |
B | 1.10.8.1190 | Mainly Alpha | Orthogonal Bundle | Helicase, Ruva Protein | domain 3 | CATH (4.3.0) |
B | 2.60.120.1680 | Mainly Beta | Sandwich | Jelly Rolls | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08715 | Coronavirus papain-like peptidase (CoV_peptidase) | Coronavirus papain-like peptidase | - | Family | |
PF08715 | Coronavirus papain-like peptidase (CoV_peptidase) | Coronavirus papain-like peptidase | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
CSO | Parent Component: CYS :  AA0205 :  L-cysteine sulfenic acid MOD:00210 | |
OCS | Parent Component: CYS :  AA0205 , AA0556 :  L-cysteine sulfenic acid MOD:00210 , L-cysteic acid (L-cysteine sulfonic acid) MOD:00460 | |
OCS | Parent Component: CYS :  AA0205 , AA0556 , AA0556 :  L-cysteine sulfenic acid MOD:00210 , L-cysteic acid (L-cysteine sulfonic acid) MOD:00460 , L-cysteic acid (L-cysteine sulfonic acid) MOD:00460 |