4OR2

Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Class C G protein-coupled receptor-like	8047349	4005598	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	G protein-coupled receptor-like	8091092	3000473	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Cytochromes	8057879	3001526	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cytochromes	8057879	3001526	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091092	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_3	e4or2A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_3	ECOD (1.6)
A	Cytochrom_B562_1	e4or2A2	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: Cytochrom_B562_1	ECOD (1.6)
B	7tm_3	e4or2B1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_3	ECOD (1.6)
B	Cytochrom_B562_1	e4or2B2	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: Cytochrom_B562_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07361	Cytochrome b562 (Cytochrom_B562)	Cytochrome b562	-	Family
A, B	PF00003	7 transmembrane sweet-taste receptor of 3 GCPR (7tm_3)	7 transmembrane sweet-taste receptor of 3 GCPR	This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G Pfam:PF07562, which is the human sweet-taste recepto ...	This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G Pfam:PF07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor Pfam:PF01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Soluble cytochrome b562, Metabotropic glutamate receptor 1	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding glutamate receptor activity G protein-coupled glutamate receptor activity molecular transducer activity binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding glutamate receptor activity G protein-coupled glutamate receptor activity molecular transducer activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration postsynaptic neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	behavior multicellular organismal process locomotory behavior system process regulation of biological process nervous system process regulation of system process biological regulation sensory perception of pain regulation of nervous system process sensory perception regulation of sensory perception regulation of multicellular organismal process regulation of sensory perception of pain behavior multicellular organismal process locomotory behavior system process regulation of biological process nervous system process regulation of system process biological regulation sensory perception of pain regulation of nervous system process sensory perception regulation of sensory perception regulation of multicellular organismal process regulation of sensory perception of pain cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication cellular process positive regulation of signaling import into cell nitrogen compound transport carboxylic acid transmembrane transport transport amino acid transmembrane transport L-amino acid transport L-glutamate import localization L-glutamate import across plasma membrane organic acid transmembrane transport organic anion transport carboxylic acid transport organic substance transport import across plasma membrane establishment of localization organic acid transport transmembrane transport amino acid transport acidic amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane L-glutamate transmembrane transport trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission cell surface receptor signaling pathway phospholipase C-activating G protein-coupled glutamate receptor signaling pathway glutamate receptor signaling pathway G protein-coupled glutamate receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic regulation of trans-synaptic signaling response to electrical stimulus cellular response to electrical stimulus response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus	periplasmic space cellular anatomical entity postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle periplasmic space cellular anatomical entity postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse G protein-coupled receptor homodimeric complex protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex plasma membrane signaling receptor complex G protein-coupled receptor complex Schaffer collateral - CA1 synapse membrane-bounded organelle intracellular organelle intracellular anatomical structure nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR010980	Cytochrome c/b562	Homologous Superfamily
A, B	IPR009155	Cytochrome b562	Family
A, B	IPR017978	GPCR family 3, C-terminal	Domain
A, B	IPR017979	GPCR, family 3, conserved site	Conserved Site
A, B	IPR001256	GPCR, family 3, metabotropic glutamate receptor 1	Family
A, B	IPR000337	GPCR, family 3	Family
A, B	IPR038550	GPCR, family 3, nine cysteines domain superfamily	Homologous Superfamily
A, B	IPR011500	GPCR, family 3, nine cysteines domain	Domain
A, B	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A, B	IPR019588	Metabotropic glutamate receptor, Homer-binding domain	Domain
A, B	IPR000162	GPCR, family 3, metabotropic glutamate receptor	Family
A, B	IPR001828	Receptor, ligand binding region	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13255	status epilepticus autosomal recessive spinocerebellar ataxia 13 fibroma temporal lobe epilepsy spinocerebellar ataxia 44 epilepsy autosomal dominant cerebellar ataxia Grand Mal Status Epilepticus malignant ependymoma oligodendroglioma Pick disease atypical teratoid rhabdoid tumor primitive neuroectodermal tumor chondromyxoid fibroma spinocerebellar ataxia type 2 status epilepticus autosomal recessive spinocerebellar ataxia 13 fibroma temporal lobe epilepsy spinocerebellar ataxia 44 epilepsy autosomal dominant cerebellar ataxia Grand Mal Status Epilepticus malignant ependymoma oligodendroglioma Pick disease atypical teratoid rhabdoid tumor primitive neuroectodermal tumor chondromyxoid fibroma spinocerebellar ataxia type 2 depressive disorder spinocerebellar ataxia type 6 fibromatosis intellectual disability malignant glioma neurodegenerative disease astrocytic tumor osteosarcoma pilocytic astrocytoma psoriasis colorectal cancer spinocerebellar ataxia type 4 spinocerebellar ataxia type 7 glioblastoma subependymal giant cell astrocytoma large cell medulloblastoma medulloblastoma attention deficit hyperactivity disorder, inattentive type pituitary cancer schizophrenia cerebellar ataxia spinocerebellar ataxia type 1 spinocerebellar ataxia type 5

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	GPCR Metabotropic glutamate receptor (C) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class C	Metabotropic Glutamate Receptor 1 (mGlu₁) with bound allosteric modulator

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.