4NEN
An internal ligand-bound, metastable state of a leukocyte integrin, aXb2
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | vWA-like | 8044051 | 3000832 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF08441 | e4nenA5 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF08441 | ECOD (1.6) |
A | PF20805 | e4nenA4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF20805 | ECOD (1.6) |
A | PF21520 | e4nenA3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF21520 | ECOD (1.6) |
A | PF01839 | e4nenA1 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: PF01839 | ECOD (1.6) |
A | PF00092 | e4nenA2 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: vWA-like | F: PF00092 | ECOD (1.6) |
B | F_UNCLASSIFIED | e4nenB9 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF07965 | e4nenB1 | A: a+b two layers | X: Integrin beta tail domain (From Topology) | H: Integrin beta tail domain (From Topology) | T: Integrin beta tail domain | F: PF07965 | ECOD (1.6) |
B | PF00362 | e4nenB8 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: vWA-like | F: PF00362 | ECOD (1.6) |
B | PF17205 | e4nenB3 | A: few secondary structure elements | X: Trefoil/Plexin domain-like (From Topology) | H: Trefoil/Plexin domain-like (From Topology) | T: Trefoil/Plexin domain-like | F: PF17205 | ECOD (1.6) |
B | F_UNCLASSIFIED | e4nenB12 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF07974 | e4nenB13 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF07974 | ECOD (1.6) |
B | PF18372 | e4nenB11 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF18372 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.130.10.130 | Mainly Beta | 7 Propeller | Methylamine Dehydrogenase | Chain H | CATH (4.3.0) |
A | 3.40.50.410 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | von Willebrand factor, type A domain | CATH (4.3.0) |
A | 2.60.40.1460 | Mainly Beta | Sandwich | Immunoglobulin-like | Integrin domains. Chain A, domain 2 | CATH (4.3.0) |
A | 2.60.40.1510 | Mainly Beta | Sandwich | Immunoglobulin-like | ntegrin, alpha v. Chain A, domain 3 | CATH (4.3.0) |
A | 2.60.40.1530 | Mainly Beta | Sandwich | Immunoglobulin-like | ntegrin, alpha v. Chain A, domain 4 | CATH (4.3.0) |
B | 2.60.40.1510 | Mainly Beta | Sandwich | Immunoglobulin-like | ntegrin, alpha v. Chain A, domain 3 | CATH (4.3.0) |
B | 3.40.50.410 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | von Willebrand factor, type A domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00092 | von Willebrand factor type A domain (VWA) | von Willebrand factor type A domain | - | Domain | |
PF21520 | Integrin alpha-X-like, Ig-like domain 3 (ITGAX-like_Ig_3) | Integrin alpha-X-like, Ig-like domain 3 | This domain is found in Integrin alpha-X from humans (ITGAX) and similar proteins predominantly found in vertebrates. ITGAX is a receptor for fibrinogen. This region composed of an immunoglobulin-like domain [1,3]. | Domain | |
PF01839 | FG-GAP repeat (FG-GAP) | FG-GAP repeat | - | Repeat | |
PF00362 | Integrin beta chain VWA domain (Integrin_beta) | Integrin beta chain VWA domain | Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain. | Domain | |
PF17205 | Integrin plexin domain (PSI_integrin) | Integrin plexin domain | This short disulphide rich domain is found at the N-terminus of integrin beta chains. | Domain | |
PF07965 | Integrin beta tail domain (Integrin_B_tail) | Integrin beta tail domain | This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions. | Domain |