4JNH

A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03276	e4jnhA1	A: a+b two layers	X: N-terminal domain of spumavirus gag protein (From Topology)	H: N-terminal domain of spumavirus gag protein (From Topology)	T: N-terminal domain of spumavirus gag protein	F: PF03276	ECOD (1.6)
B	PF03276	e4jnhB1	A: a+b two layers	X: N-terminal domain of spumavirus gag protein (From Topology)	H: N-terminal domain of spumavirus gag protein (From Topology)	T: N-terminal domain of spumavirus gag protein	F: PF03276	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.1500	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.1500	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03276	Spumavirus gag protein, N-terminal (Gag_spuma_N)	Spumavirus gag protein, N-terminal	This is the conserved N-terminal domain of the Gag polyprotein from Foamyviruses (FVs) or Spuma-retroviruses. Gag is the major structural protein required for genome packaging virion assembly, trafficking and egress. This region corresponds to the En ...	This is the conserved N-terminal domain of the Gag polyprotein from Foamyviruses (FVs) or Spuma-retroviruses. Gag is the major structural protein required for genome packaging virion assembly, trafficking and egress. This region corresponds to the Env-binding domain containing the cytoplasmic targeting and retention sequence (CTRS) [1,2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Gag polyprotein	DNA binding binding organic cyclic compound binding nucleic acid binding RNA binding	exit from host cell biological process involved in interspecies interaction between organisms viral process viral release from host cell viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus transport of virus transport of viral material towards nucleus symbiont entry into host cell symbiont entry into host exit from host cell biological process involved in interspecies interaction between organisms viral process viral release from host cell viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus transport of virus transport of viral material towards nucleus symbiont entry into host cell symbiont entry into host virion assembly viral budding viral budding via host ESCRT complex	host cellular component host intracellular part host cytoskeleton host cell part host intracellular region cellular anatomical entity host intracellular organelle host intracellular membrane-bounded organelle host cell nucleus viral nucleocapsid viral capsid virion component host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004957	Gag polyprotein, N-terminal domain	Domain
A, B	IPR049099	Gag polyprotein, C-terminal	Domain
A, B	IPR049101	Gag polyprotein, conserved central domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.