4IJJ

Structure of transcription factor DksA2 from Pseudomonas aeruginosa

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21157	e4ijjA1	A: alpha bundles	X: Long alpha-hairpin	H: DnaK suppressor protein DksA, alpha-hairpin domain (From Topology)	T: DnaK suppressor protein DksA, alpha-hairpin domain	F: PF21157	ECOD (1.6)
A	PF01258	e4ijjA2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01258	ECOD (1.6)
B	PF21157	e4ijjB2	A: alpha bundles	X: Long alpha-hairpin	H: DnaK suppressor protein DksA, alpha-hairpin domain (From Topology)	T: DnaK suppressor protein DksA, alpha-hairpin domain	F: PF21157	ECOD (1.6)
B	PF01258	e4ijjB1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01258	ECOD (1.6)
C	PF21157	e4ijjC1	A: alpha bundles	X: Long alpha-hairpin	H: DnaK suppressor protein DksA, alpha-hairpin domain (From Topology)	T: DnaK suppressor protein DksA, alpha-hairpin domain	F: PF21157	ECOD (1.6)
C	PF01258	e4ijjC2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01258	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.910	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	DksA, coiled-coil domain	CATH (4.3.0)
B	1.20.120.910	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	DksA, coiled-coil domain	CATH (4.3.0)
C	1.20.120.910	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	DksA, coiled-coil domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF21157	DnaK suppressor protein DksA, N-terminal domain (DksA_N)	DnaK suppressor protein DksA, N-terminal domain	DksA is a transcription factor that directly binds RNA polymerase and controls the bacteria response to stress and starvation. DksA is all helical and comprises a coiled-coil (CC) and globular domains [1-4]. This is the N-terminal domain which extend ...	DksA is a transcription factor that directly binds RNA polymerase and controls the bacteria response to stress and starvation. DksA is all helical and comprises a coiled-coil (CC) and globular domains [1-4]. This is the N-terminal domain which extends through the secondary channel toward the RNAP active site and serves as a conduit for the substrate NTPs. This domain consists of two helices arranged in an antiparallel alpha-hairpin with left-handed twist.	Domain
A, B, C	PF01258	Prokaryotic dksA/traR C4-type zinc finger (zf-dskA_traR)	Prokaryotic dksA/traR C4-type zinc finger	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Putative C4-type zinc finger protein, DksA/TraR family	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR037187	DksA, N-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR000962	Zinc finger, DksA/TraR C4-type	Domain
A, B, C	IPR048489	DnaK suppressor protein DksA, N-terminal domain	Domain
A, B, C	IPR012784	RNA polymerase-binding transcription factor DksA	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.