4IAP

Crystal structure of PH domain of Osh3 from Saccharomyces cerevisiae

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH_8	e4iapA2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH_8	ECOD (1.6)
A	Phage_lysozyme_2	e4iapA1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	PH_8	e4iapB2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH_8	ECOD (1.6)
B	Phage_lysozyme_2	e4iapB1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
A	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15409	Pleckstrin homology domain (PH_8)	Pleckstrin homology domain	This Pleckstrin homology domain is found in some fungal species.	Domain
A, B	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Oxysterol-binding protein homolog 3,Endolysin,Oxysterol-binding protein homolog 3	sterol binding binding organic cyclic compound binding steroid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity sterol binding binding organic cyclic compound binding steroid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity	pseudohyphal growth growth cellular process growth of unicellular organism as a thread of attached cells filamentous growth cell growth filamentous growth of a population of unicellular organisms invasive growth in response to glucose limitation invasive filamentous growth localization import into cell transport endocytosis establishment of localization pseudohyphal growth growth cellular process growth of unicellular organism as a thread of attached cells filamentous growth cell growth filamentous growth of a population of unicellular organisms invasive growth in response to glucose limitation invasive filamentous growth localization import into cell transport endocytosis establishment of localization vesicle-mediated transport catabolic process macroautophagy cellular metabolic process autophagy piecemeal microautophagy of the nucleus microautophagy cellular catabolic process metabolic process nucleophagy process utilizing autophagic mechanism sexual reproduction reproductive process conjugation with cellular fusion organelle fusion cellular component organization organelle organization nucleus organization karyogamy karyogamy involved in conjugation with cellular fusion cellular component organization or biogenesis maintenance of cell polarity establishment or maintenance of cell polarity secretion by cell exocytosis secretion export from cell macromolecule localization organic substance transport lipid localization lipid transport sterol transport organic hydroxy compound transport cellular localization nitrogen compound transport ER to Golgi ceramide transport intracellular lipid transport intracellular transport ceramide transport amide transport establishment of localization in cell biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process organic substance metabolic process aminoglycan metabolic process peptidoglycan metabolic process macromolecule metabolic process organic substance catabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle endomembrane system perinuclear endoplasmic reticulum perinuclear region of cytoplasm intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle endomembrane system perinuclear endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane cell cortex cortical endoplasmic reticulum endoplasmic reticulum tubular network host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR041680	Pleckstrin homology domain 8	Domain
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR018494	Oxysterol-binding protein, conserved site	Conserved Site
A, B	IPR037239	Oxysterol-binding protein superfamily	Homologous Superfamily
A, B	IPR000648	Oxysterol-binding protein	Family
A, B	IPR036598	GOLD domain superfamily	Homologous Superfamily
A, B	IPR001165	T4-type lysozyme	Family
A, B	IPR034690	Endolysin T4 type	Family
A, B	IPR002196	Glycoside hydrolase, family 24	Family
A, B	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, B	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Monotopic/peripheral	All beta monotopic/peripheral	PH domain-like	Pleckstrin-homology domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.