4HKR

Calcium release-activated calcium (CRAC) channel ORAI

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Calcium release-activated calcium (CRAC) channel ORAI-like	8095816	3002705	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Calcium release-activated calcium (CRAC) channel ORAI-like	8095816	3002705	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Orai-1	e4hkrA1	A: alpha bundles	X: Calcium release-activated calcium channel protein 1 (From Topology)	H: Calcium release-activated calcium channel protein 1 (From Topology)	T: Calcium release-activated calcium channel protein 1	F: Orai-1	ECOD (1.6)
B	Orai-1	e4hkrB2	A: alpha bundles	X: Calcium release-activated calcium channel protein 1 (From Topology)	H: Calcium release-activated calcium channel protein 1 (From Topology)	T: Calcium release-activated calcium channel protein 1	F: Orai-1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.140.140	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)
B	1.20.140.140	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07856	Mediator of CRAC channel activity (Orai-1)	Mediator of CRAC channel activity	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Calcium release-activated calcium channel protein 1	calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity store-operated calcium channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity store-operated calcium channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity identical protein binding protein binding binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport store-operated calcium entry developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development regulation of localization regulation of calcium ion transport positive regulation of calcium ion transport regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process positive regulation of transport positive regulation of monoatomic ion transport regulation of metal ion transport calcineurin-NFAT signaling cascade cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling signal transduction positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of cellular process regulation of signaling positive regulation of calcineurin-mediated signaling positive regulation of intracellular signal transduction calcium-mediated signaling regulation of response to stimulus regulation of cell communication calcineurin-mediated signaling positive regulation of signaling	membrane cellular anatomical entity cell periphery plasma membrane protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012446	Calcium release-activated calcium channel protein	Family
A, B	IPR038350	Orai superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				Calcium release-activated calcium (CRAC) channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Calcium Ion-Selective	Orai Calcium release-activated calcium (CRAC) channel

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.