4DU0

Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00323	e4du0A1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: PF00323	ECOD (1.6)
B	PF00323	e4du0B1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: PF00323	ECOD (1.6)
C	PF00323	e4du0C1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: PF00323	ECOD (1.6)
D	PF00323	e4du0D1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: PF00323	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00323	Mammalian defensin (Defensin_1)	Mammalian defensin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Neutrophil defensin 1	pore-forming activity	response to stimulus immune response immune system process humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stimulus immune response immune system process humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus cellular response to stimulus response to organic substance response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to chemical cellular response to lipid cellular process cellular response to organic substance response to molecule of bacterial origin regulation of cellular process intracellular receptor signaling pathway signaling intracellular estrogen receptor signaling pathway hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone signal transduction cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound steroid hormone mediated signaling pathway nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway disruption of cellular anatomical structure in another organism disruption of anatomical structure in another organism disruption of plasma membrane integrity in another organism chemotaxis taxis locomotion defense response to protozoan response to protozoan disruption of cell in another organism biological process involved in symbiotic interaction killing by host of symbiont cells biological process involved in interaction with symbiont killing of cells of another organism cell killing innate immune response in mucosa innate immune response mucosal immune response organ or tissue specific immune response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to fungus response to fungus defense response to Gram-negative bacterium defense response to virus response to virus cell chemotaxis lymphocyte chemotaxis lymphocyte migration leukocyte migration mononuclear cell migration T cell chemotaxis cell migration cell motility T cell migration leukocyte chemotaxis defense response to Gram-positive bacterium	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen secretory granule primary lysosome secretory vesicle cytoplasm Golgi apparatus Golgi lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016327	Alpha-defensin	Family
A, B, C, D	IPR006081	Alpha-defensin, C-terminal	Domain
A, B, C, D	IPR006080	Beta/alpha-defensin, C-terminal	Domain
A, B, C, D	IPR002366	Alpha-defensin, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P59665	IgA glomerulonephritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.