4CHF

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21490	e4chfA1	A: a+b three layers	X: Polymerase basic protein 2 cap-binding domain (From Topology)	H: Polymerase basic protein 2 cap-binding domain (From Topology)	T: Polymerase basic protein 2 cap-binding domain	F: PF21490	ECOD (1.6)
B	PF21490	e4chfB1	A: a+b three layers	X: Polymerase basic protein 2 cap-binding domain (From Topology)	H: Polymerase basic protein 2 cap-binding domain (From Topology)	T: Polymerase basic protein 2 cap-binding domain	F: PF21490	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A, B	PF21490	Polymerase basic protein 2, cap-binding domain (PB2_cap-binding)	Polymerase basic protein 2, cap-binding domain	Polymerase basic protein 2 (PB2) is a subunit of the RNA-dependent RNA polymerase of Orthomyxovirus Influenza A virus (IAV) which performs transcription of viral mRNAs by cap-snatching, a processes that generated capped primers by host pre-mRNA bindi ...	Polymerase basic protein 2 (PB2) is a subunit of the RNA-dependent RNA polymerase of Orthomyxovirus Influenza A virus (IAV) which performs transcription of viral mRNAs by cap-snatching, a processes that generated capped primers by host pre-mRNA binding, mediated by PB2 [1]. This protein has two domains, the cap-binding and the so-called '627-domain'. This entry represents the cap-binding domain and includes PB2 from Thogoto (THOV) virus, which is similar to IAV [1].	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	POLYMERASE BASIC PROTEIN 2	-	cellular biosynthetic process RNA metabolic process 7-methylguanosine RNA capping RNA capping mRNA processing nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process RNA processing 7-methylguanosine mRNA capping cellular metabolic process primary metabolic process gene expression cellular biosynthetic process RNA metabolic process 7-methylguanosine RNA capping RNA capping mRNA processing nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process RNA processing 7-methylguanosine mRNA capping cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process viral gene expression cap snatching negative stranded viral RNA transcription viral process viral transcription RNA-templated viral transcription	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle virion component

Chains	Accession	Name	Type
A, B	IPR049113	Polymerase basic protein 2, helical domain	Domain
A, B	IPR048838	Polymerase basic protein 2, '627' domain	Domain
A, B	IPR048837	Polymerase basic protein 2, cap-binding domain	Domain