Annotations: 4C3D

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	VP30 CTD-like	8052489	3002122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	CCCH zinc finger-like	8052492	3001741	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CCCH zinc finger-like	8052492	3001741	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	VP30 CTD-like	8052489	3002122	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pneumovirus_M2_C	e4c3dA3	A: alpha arrays	X: Matrix protein 2-1 core domain (From Topology)	H: Matrix protein 2-1 core domain (From Topology)	T: Matrix protein 2-1 core domain	F: Pneumovirus_M2_C	ECOD (1.6)
A	Pneumovirus_M2_N	e4c3dA4	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: Pneumovirus_M2_N	ECOD (1.6)
B	Pneumovirus_M2_C	e4c3dB3	A: alpha arrays	X: Matrix protein 2-1 core domain (From Topology)	H: Matrix protein 2-1 core domain (From Topology)	T: Matrix protein 2-1 core domain	F: Pneumovirus_M2_C	ECOD (1.6)
B	Pneumovirus_M2_N	e4c3dB4	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: Pneumovirus_M2_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.1350	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Pneumovirus matrix protein 2 (M2), zinc-binding domain	CATH (4.3.0)
B	1.20.120.1350	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Pneumovirus matrix protein 2 (M2), zinc-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06436	Pneumovirus matrix protein 2 (M2) (Pneumovirus_M2)	Pneumovirus matrix protein 2 (M2)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MATRIX M2-1	structural molecule activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	negative regulation of termination of DNA-templated transcription regulation of cellular process negative regulation of biological process protein-containing complex disassembly positive regulation of macromolecule biosynthetic process regulation of protein-containing complex disassembly negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of termination of DNA-templated transcription regulation of cellular process negative regulation of biological process protein-containing complex disassembly positive regulation of macromolecule biosynthetic process regulation of protein-containing complex disassembly negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process cellular component disassembly negative regulation of DNA-templated transcription regulation of biological process negative regulation of cellular component organization cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of termination of DNA-templated transcription regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of cellular component organization transcription antitermination cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process DNA-templated transcription termination RNA biosynthetic process cellular component organization nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process negative regulation of protein-containing complex disassembly negative regulation of cellular process cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process protein-containing complex organization biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression negative regulation of biosynthetic process cellular process positive regulation of cellular biosynthetic process viral gene expression viral process viral transcription regulation of viral process regulation of viral transcription	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle virion component host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009452	Pneumovirus matrix 2-1	Family
A, B	IPR000571	Zinc finger, CCCH-type	Domain
A, B	IPR036855	Zinc finger, CCCH-type superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.