3RED

3.0 A structure of the Prunus mume hydroxynitrile lyase isozyme-1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	GMC oxidoreductase-like	8088156	4000122	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Flavoreductase-like	8088157	3000055	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Flavoreductase-like	8088157	3000055	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05199	e3redA2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
A	PF00732,PF05199	e3redA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
B	PF05199	e3redB1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
B	PF00732,PF05199	e3redB3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
C	PF05199	e3redC1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
C	PF00732,PF05199	e3redC3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
D	PF05199	e3redD1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
D	PF00732,PF05199	e3redD3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
E	PF05199	e3redE1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
E	PF00732,PF05199	e3redE3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
F	PF05199	e3redF1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
F	PF00732,PF05199	e3redF3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
G	PF05199	e3redG1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
G	PF00732,PF05199	e3redG3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
H	PF05199	e3redH1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
H	PF00732,PF05199	e3redH3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
I	PF05199	e3redI1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
I	PF00732,PF05199	e3redI3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
J	PF05199	e3redJ1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
J	PF00732,PF05199	e3redJ3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
K	PF05199	e3redK1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
K	PF00732,PF05199	e3redK3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)
L	PF05199	e3redL1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: PF05199	ECOD (1.6)
L	PF00732,PF05199	e3redL3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00732,PF05199	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
A	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
B	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
B	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
C	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
C	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
D	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
D	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
E	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
E	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
F	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
F	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
G	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
G	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
H	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
H	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
I	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
I	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
J	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
J	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
K	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
K	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)
L	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
L	3.30.410.40	Alpha Beta	2-Layer Sandwich	Cholesterol Oxidase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00732	GMC oxidoreductase (GMC_oxred_N)	GMC oxidoreductase	This family of proteins bind FAD as a cofactor.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF05199	GMC oxidoreductase (GMC_oxred_C)	GMC oxidoreductase	This domain found associated with Pfam:PF00732.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Hydroxynitrile lyase	mandelonitrile lyase activity lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding mandelonitrile lyase activity lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000172	Glucose-methanol-choline oxidoreductase, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR012132	Glucose-methanol-choline oxidoreductase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily