3O9U

Effector domain of influenza A/PR/8/34 NS1

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Flu_NS1_C	e3o9uB1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
B [auth A]	Flu_NS1_C	e3o9uA1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
C	Flu_NS1_C	e3o9uC1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
D	Flu_NS1_C	e3o9uD1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
E	Flu_NS1_C	e3o9uE1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
F	Flu_NS1_C	e3o9uF1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
G	Flu_NS1_C	e3o9uG1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)
H	Flu_NS1_C	e3o9uH1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B [auth A]	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
D	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
E	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
F	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
G	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
H	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	PF00600	Influenza non-structural protein (NS1) (Flu_NS1)	Influenza non-structural protein (NS1)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	Nonstructural protein 1	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity RNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity RNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host PKR/eIFalpha signaling symbiont-mediated perturbation of host translation biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host-directed shutoff of host translation modulation by symbiont of host process symbiont-mediated perturbation of host gene expression cellular process symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host PKR/eIFalpha signaling symbiont-mediated perturbation of host translation biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host-directed shutoff of host translation modulation by symbiont of host process symbiont-mediated perturbation of host gene expression cellular process symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host defense response response to host defenses response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway symbiont-mediated suppression of host mRNA processing symbiont-mediated suppression of host gene expression	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR038064	Influenza A virus NS1, effector domain-like superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR009068	uS15/NS1, RNA-binding domain superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR000256	Influenza A virus NS1 protein	Family
A [auth B], B [auth A], C, D, E, A [auth B], B [auth A], C, D, E, F, G, H	IPR004208	Influenza non-structural protein (NS1)	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.