Annotations: 3NVN

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01403	e3nvnA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01403	ECOD (1.6)
B	F_UNCLASSIFIED	e3nvnB3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF01437	e3nvnB2	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: PF01437	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01403	Sema domain (Sema)	Sema domain	-	Repeat
B	PF01437	Plexin repeat (PSI)	Plexin repeat	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	EVM139	protein binding binding semaphorin receptor binding signaling receptor binding	-	extracellular region cellular anatomical entity
B	Plexin-C1	protein binding binding signaling receptor binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity semaphorin receptor activity	multicellular organismal process positive regulation of nervous system development axonogenesis regulation of cellular process cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation multicellular organismal process positive regulation of nervous system development axonogenesis regulation of cellular process cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization system development developmental process regulation of biological process regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis positive regulation of cellular process regulation of multicellular organismal development plasma membrane bounded cell projection organization biological regulation axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization cellular component disassembly regulation of synapse pruning cell junction disassembly synapse pruning regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion regulation of cell shape regulation of cell morphogenesis cell adhesion regulation of cell adhesion negative regulation of cellular process negative regulation of biological process negative regulation of cell adhesion cellular response to stimulus response to stimulus semaphorin-plexin signaling pathway signaling cell communication signal transduction semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance cell surface receptor signaling pathway axon guidance neuron projection guidance	membrane cellular anatomical entity cell periphery plasma membrane protein-containing complex semaphorin receptor complex receptor complex cerebellar climbing fiber to Purkinje cell synapse neuron to neuron synapse synapse cell junction asymmetric synapse glutamatergic synapse excitatory synapse membrane cellular anatomical entity cell periphery plasma membrane protein-containing complex semaphorin receptor complex receptor complex cerebellar climbing fiber to Purkinje cell synapse neuron to neuron synapse synapse cell junction asymmetric synapse glutamatergic synapse excitatory synapse asymmetric, glutamatergic, excitatory synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036352	Sema domain superfamily	Homologous Superfamily
A	IPR001627	Sema domain	Domain
A	IPR027231	Semaphorin	Family
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B	IPR002909	IPT domain	Domain
B	IPR016201	PSI domain	Domain
B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B	IPR002165	Plexin repeat	Repeat
B	IPR041853	Plexin-C1, Sema domain	Domain
B	IPR031148	Plexin family	Family
B	IPR046800	Plexin, cytoplasmic RhoGTPase-binding domain	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR013548	Plexin, cytoplasmic RasGAP domain	Domain
B	IPR036352	Sema domain superfamily	Homologous Superfamily
B	IPR001627	Sema domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: O60486	endometriosis pancreatic ductal adenocarcinoma Sjogren syndrome adrenal cortex carcinoma chronic obstructive pulmonary disease Endometrioma glioblastoma invasive ductal breast carcinoma malignant mesothelioma osteosarcoma psoriasis tuberculosis atypical teratoid rhabdoid tumor Crohn disease head and neck cancer endometriosis pancreatic ductal adenocarcinoma Sjogren syndrome adrenal cortex carcinoma chronic obstructive pulmonary disease Endometrioma glioblastoma invasive ductal breast carcinoma malignant mesothelioma osteosarcoma psoriasis tuberculosis atypical teratoid rhabdoid tumor Crohn disease head and neck cancer large cell medulloblastoma malignant pancreatic neoplasm ovarian cancer sarcoidosis ulcerative colitis B-cell chronic lymphocytic leukemia diabetes mellitus gastric carcinoma interstitial cystitis lung cancer medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.