3MWP

Nucleoprotein structure of lassa fever virus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3mwpa2	All alpha proteins	Arenavirus nucleocapsid protein-like	Arenavirus nucleocapsid protein N-terminal domain-like	Arenavirus nucleocapsid protein N-terminal domain	Lassa virus (LASV) nucleoprotein (NP), N-terminal domain	LASV (Lassa virus Josiah ) [TaxId: 11622 ],	SCOPe (2.08)
A	d3mwpa1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	DnaQ-like 3'-5' exonuclease	Arenavirus nucleoprotein C-terminal domain	LASV (Lassa virus Josiah ) [TaxId: 11622 ],	SCOPe (2.08)
B	d3mwpb2	All alpha proteins	Arenavirus nucleocapsid protein-like	Arenavirus nucleocapsid protein N-terminal domain-like	Arenavirus nucleocapsid protein N-terminal domain	Lassa virus (LASV) nucleoprotein (NP), N-terminal domain	LASV (Lassa virus Josiah ) [TaxId: 11622 ],	SCOPe (2.08)
B	d3mwpb1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	DnaQ-like 3'-5' exonuclease	Arenavirus nucleoprotein C-terminal domain	LASV (Lassa virus Josiah ) [TaxId: 11622 ],	SCOPe (2.08)
C	d3mwpc2	All alpha proteins	Arenavirus nucleocapsid protein-like	Arenavirus nucleocapsid protein N-terminal domain-like	Arenavirus nucleocapsid protein N-terminal domain	Lassa virus (LASV) nucleoprotein (NP), N-terminal domain	LASV (Lassa virus Josiah ) [TaxId: 11622 ],	SCOPe (2.08)
C	d3mwpc1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Ribonuclease H-like	DnaQ-like 3'-5' exonuclease	Arenavirus nucleoprotein C-terminal domain	LASV (Lassa virus Josiah ) [TaxId: 11622 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Arenavirus nucleoprotein C-terminal domain-like	8046803	4005307	SCOP2 (2022-06-29)
A	SCOP2 Family	Arenavirus nucleoprotein N-terminal domain-like	8048312	4006049	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribonuclease H-like	8053524	3000143	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Arenavirus nucleoprotein N-terminal domain-like	8053525	3002201	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ribonuclease H-like	8053524	3000143	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Arenavirus nucleoprotein N-terminal domain-like	8053525	3002201	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribonuclease H-like	8053524	3000143	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Arenavirus nucleoprotein N-terminal domain-like	8053525	3002201	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arena_nucleocap	e3mwpA1	A: alpha complex topology	X: N-terminal domain in Lassa fever virus nucleoprotein (From Topology)	H: N-terminal domain in Lassa fever virus nucleoprotein (From Topology)	T: N-terminal domain in Lassa fever virus nucleoprotein	F: Arena_nucleocap	ECOD (1.6)
A	Arena_ncap_C	e3mwpA2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Arena_ncap_C	ECOD (1.6)
B	Arena_nucleocap	e3mwpB1	A: alpha complex topology	X: N-terminal domain in Lassa fever virus nucleoprotein (From Topology)	H: N-terminal domain in Lassa fever virus nucleoprotein (From Topology)	T: N-terminal domain in Lassa fever virus nucleoprotein	F: Arena_nucleocap	ECOD (1.6)
B	Arena_ncap_C	e3mwpB2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Arena_ncap_C	ECOD (1.6)
C	Arena_nucleocap	e3mwpC1	A: alpha complex topology	X: N-terminal domain in Lassa fever virus nucleoprotein (From Topology)	H: N-terminal domain in Lassa fever virus nucleoprotein (From Topology)	T: N-terminal domain in Lassa fever virus nucleoprotein	F: Arena_nucleocap	ECOD (1.6)
C	Arena_ncap_C	e3mwpC2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Arena_ncap_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.410	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B	3.30.420.410	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.30.420.410	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Nucleoprotein	nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response response to host defenses response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus biological process involved in interaction with host symbiont-mediated suppression of host signal transduction pathway modulation by symbiont of host process cellular process symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity viral gene expression viral process viral transcription RNA-templated viral transcription cellular biosynthetic process RNA metabolic process viral life cycle RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral RNA genome replication organic substance biosynthetic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process negative stranded viral RNA replication viral genome replication biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process	protein-containing complex ribonucleoprotein complex viral nucleocapsid viral capsid virion component host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity helical viral capsid

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR038115	Nucleocapsid, C-terminal superfamily	Homologous Superfamily
A, B, C	IPR001680	WD40 repeat	Repeat
A, B, C	IPR000229	Nucleocapsid protein, arenaviridae	Family
A, B, C	IPR035083	Nucleocapsid, N-terminal, Arenaviridae	Domain
A, B, C	IPR035084	Nucleocapsid, C-terminal, Arenaviridae	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.