3MTU

Structure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E	d3mtue1	Coiled coil proteins	Parallel coiled-coil	Head morphogenesis protein gp7	Head morphogenesis protein gp7	automated matches	(Salasvirus phi29 ) [TaxId: 10756 ], Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
E	d3mtue2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Salasvirus phi29 ) [TaxId: 10756 ], Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
F	d3mtuf1	Coiled coil proteins	Parallel coiled-coil	Head morphogenesis protein gp7	Head morphogenesis protein gp7	automated matches	(Salasvirus phi29 ) [TaxId: 10756 ], Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
F	d3mtuf2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Salasvirus phi29 ) [TaxId: 10756 ], Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03271	e3mtuA1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
B	PF03271	e3mtuB1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
C	PF03271	e3mtuC1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
D	PF03271	e3mtuD1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E	1.20.5.400	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
F	1.20.5.400	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03271	EB1-like C-terminal motif (EB1)	EB1-like C-terminal motif	-	Family
A, B, C, D	PF00261	Tropomyosin (Tropomyosin)	Tropomyosin	-	Coiled-coil
E, F	PF00261	Tropomyosin (Tropomyosin)	Tropomyosin	-	Coiled-coil
E, F	PF11418	Phi29 scaffolding protein (Scaffolding_pro)	Phi29 scaffolding protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Tropomyosin alpha-1 chain,Microtubule-associated protein RP/EB family member 1	protein heterodimerization activity protein binding binding protein dimerization activity cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding identical protein binding protein homodimerization activity RNA binding organic cyclic compound binding nucleic acid binding kinase binding protein heterodimerization activity protein binding binding protein dimerization activity cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding identical protein binding protein homodimerization activity RNA binding organic cyclic compound binding nucleic acid binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding molecular adaptor activity microtubule plus-end binding microtubule binding tubulin binding	cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization heart process multicellular organismal process system process circulatory system process cardiac muscle contraction cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization heart process multicellular organismal process system process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction microtubule bundle formation microtubule cytoskeleton organization microtubule-based process protein localization localization cellular localization cellular macromolecule localization macromolecule localization protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle protein localization to centrosome regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process negative regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization negative regulation of supramolecular fiber organization protein polymerization regulation of biological process negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization biological regulation regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization regulation of microtubule cytoskeleton organization establishment of organelle localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation establishment of localization nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization cell division cell migration cell motility organelle assembly non-membrane-bounded organelle assembly spindle assembly spindle organization plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cilium assembly non-motile cilium assembly cilium organization cell projection assembly protein localization to astral microtubule protein localization to microtubule protein localization to cytoplasmic microtubule protein localization to spindle microtubule spindle localization establishment or maintenance of cell polarity establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation microtubule cytoskeleton organization involved in mitosis establishment of cell polarity establishment of mitotic spindle orientation positive regulation of organelle organization positive regulation of cellular component organization positive regulation of biological process positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of cellular process positive regulation of microtubule polymerization or depolymerization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization positive regulation of microtubule polymerization	polymeric cytoskeletal fiber intracellular anatomical structure actin filament cellular anatomical entity actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cell periphery polymeric cytoskeletal fiber intracellular anatomical structure actin filament cellular anatomical entity actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cell periphery plasma membrane membrane cytoplasm anchoring junction cell junction focal adhesion cell-substrate junction spindle spindle midzone microtubule cytoskeleton centrosome microtubule organizing center mitotic spindle aster spindle microtubule cytoplasmic microtubule mitotic spindle astral microtubule end microtubule end mitotic spindle astral microtubule astral microtubule microtubule microtubule plus-end cytosol cell projection plasma membrane region cell projection membrane plasma membrane bounded cell projection membrane-bounded organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system cell cortex cortical cytoskeleton cortical microtubule cytoskeleton mitotic spindle pole spindle pole cilium ciliary basal body
E, F	Capsid assembly scaffolding protein,Tropomyosin alpha-1 chain	protein heterodimerization activity protein binding binding protein dimerization activity cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding identical protein binding protein homodimerization activity DNA binding organic cyclic compound binding nucleic acid binding	cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization heart process multicellular organismal process system process circulatory system process cardiac muscle contraction cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization heart process multicellular organismal process system process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction virion assembly viral process viral life cycle	polymeric cytoskeletal fiber intracellular anatomical structure actin filament cellular anatomical entity actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cell periphery polymeric cytoskeletal fiber intracellular anatomical structure actin filament cellular anatomical entity actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle cell periphery plasma membrane membrane cytoplasm protein-containing complex viral capsid virion component viral scaffold

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000533	Tropomyosin	Family
A, B, C, D	IPR001715	Calponin homology domain	Domain
A, B, C, D	IPR004953	EB1, C-terminal	Domain
A, B, C, D	IPR027328	Microtubule-associated protein RP/EB	Family
A, B, C, D	IPR036133	EB1, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR036872	CH domain superfamily	Homologous Superfamily
E, F	IPR000533	Tropomyosin	Family
E, F	IPR038032	Capsid assembly scaffolding protein Gp7	Homologous Superfamily
E, F	IPR024374	Bacteriophage phi-29 scaffolding protein Gp7	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q15691	Weight Gain primitive neuroectodermal tumor astrocytic tumor coronary artery disease inflammatory bowel disease lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor dermatomyositis juvenile dermatomyositis malignant ependymoma myocardial ischemia osteosarcoma Weight Gain primitive neuroectodermal tumor astrocytic tumor coronary artery disease inflammatory bowel disease lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor dermatomyositis juvenile dermatomyositis malignant ependymoma myocardial ischemia osteosarcoma polycystic ovary syndrome breast carcinoma glioblastoma large cell medulloblastoma malignant glioma nicotine dependence ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.