3MQP

Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bcl-2	e3mqpA1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family
B	PF15150	Phorbol-12-myristate-13-acetate-induced (PMAIP1)	Phorbol-12-myristate-13-acetate-induced	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Bcl-2-related protein A1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity	cellular response to stimulus regulation of biological process regulation of cellular process signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling biological regulation cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand cellular process cellular response to stimulus regulation of biological process regulation of cellular process signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling biological regulation cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand cellular process signal transduction apoptotic process programmed cell death intracellular signal transduction cellular response to stress DNA damage response response to stress intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway organelle fusion cellular component organization organelle organization mitochondrial fusion cellular component organization or biogenesis mitochondrion organization negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process apoptotic mitochondrial changes release of cytochrome c from mitochondria	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane
B	Phorbol-12-myristate-13-acetate-induced protein 1	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential regulation of biological process regulation of cellular process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential regulation of biological process regulation of cellular process signaling cell death intracellular signal transduction cell communication apoptotic signaling pathway signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death cellular metabolic process reactive oxygen species metabolic process metabolic process signal transduction by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization apoptotic mitochondrial changes positive regulation of biological process regulation of release of cytochrome c from mitochondria cellular component organization positive regulation of release of cytochrome c from mitochondria cellular component organization or biogenesis positive regulation of cellular process mitochondrion organization regulation of organelle organization release of cytochrome c from mitochondria organelle organization regulation of mitochondrion organization cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of glucose metabolic process regulation of small molecule metabolic process small molecule metabolic process positive regulation of carbohydrate metabolic process positive regulation of small molecule metabolic process regulation of carbohydrate metabolic process regulation of metabolic process regulation of glucose metabolic process glucose metabolic process regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of molecular function regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process regulation of cysteine-type endopeptidase activity regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis positive regulation of cell communication positive regulation of signal transduction regulation of cellular response to stress regulation of response to endoplasmic reticulum stress regulation of signal transduction intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of response to endoplasmic reticulum stress regulation of intracellular signal transduction regulation of response to stress response to endoplasmic reticulum stress regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors cell surface receptor signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors DNA damage response, signal transduction by p53 class mediator regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of DNA damage response, signal transduction by p53 class mediator signal transduction in response to DNA damage biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus membrane organization transport establishment of localization mitochondrial membrane organization localization regulation of membrane permeability regulation of mitochondrial membrane permeability mitochondrial transport response to organic substance response to dsRNA response to nitrogen compound response to organic cyclic compound	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol protein-containing complex Bcl-2 family protein complex mitochondrial membrane membrane organelle outer membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol protein-containing complex Bcl-2 family protein complex mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
A	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
A	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A	IPR013282	Bcl-2-related protein A1	Family
A	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A	IPR002475	Bcl2-like	Family
A	IPR026298	Bcl-2 family	Family
B	IPR024140	Phorbol-12-myristate-13-acetate-induced protein 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q16548	rheumatoid arthritis esophageal cancer breast carcinoma malignant mesothelioma Mammary Neoplasms nasopharyngeal carcinoma osteosarcoma Sjogren syndrome bipolar disorder chronic obstructive pulmonary disease ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma lung cancer malignant ependymoma rheumatoid arthritis esophageal cancer breast carcinoma malignant mesothelioma Mammary Neoplasms nasopharyngeal carcinoma osteosarcoma Sjogren syndrome bipolar disorder chronic obstructive pulmonary disease ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma lung cancer malignant ependymoma neoplasm of esophagus psoriasis ulcerative colitis breast cancer cutaneous lupus erythematosus head and neck cancer large cell medulloblastoma lung carcinoma malignant glioma malignant pancreatic neoplasm medulloblastoma non-small cell lung carcinoma cystic fibrosis gastric carcinoma interstitial cystitis lung adenocarcinoma lymphoplasmacytic lymphoma
B	Pharos: Q13794	B-cell chronic lymphocytic leukemia lung cancer malignant ependymoma malignant pancreatic neoplasm non-small cell lung carcinoma acute myeloid leukemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Drug abuse primitive neuroectodermal tumor Sjogren syndrome gastric cancer substance-related disorder hematologic disease ulcerative colitis B-cell chronic lymphocytic leukemia lung cancer malignant ependymoma malignant pancreatic neoplasm non-small cell lung carcinoma acute myeloid leukemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Drug abuse primitive neuroectodermal tumor Sjogren syndrome gastric cancer substance-related disorder hematologic disease ulcerative colitis large cell medulloblastoma lymphatic system disease malignant glioma medulloblastoma adrenal cortex carcinoma pancreatic ductal adenocarcinoma bipolar disorder pituitary cancer psoriasis drug dependence spina bifida ductal breast carcinoma in situ substance dependence gastric carcinoma hepatocellular carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma malignant mesothelioma nasopharyngeal carcinoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous carcinoma cancer pterygium substance abuse exocrine pancreatic carcinoma glioblastoma transitional cell carcinoma invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.