Annotations: 3L1P

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Homeodomain-like	8057615	3000001	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Homeodomain-like	8057615	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00046	e3l1pA4	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)
A	PF00157	e3l1pA3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00157	ECOD (1.6)
B	PF00046	e3l1pB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)
B	PF00157	e3l1pB2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00157	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
A	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)
B	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
B	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00046	Homeodomain (Homeodomain)	Homeodomain	-	Domain
A, B	PF00157	Pou domain - N-terminal to homeobox domain (Pou)	Pou domain - N-terminal to homeobox domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	POU domain, class 5, transcription factor 1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity cis-regulatory region sequence-specific DNA binding protein binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity cis-regulatory region sequence-specific DNA binding protein binding HMG box domain binding protein domain specific binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding POU domain binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding cytokine binding chromatin DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding	developmental process trophectodermal cell differentiation multicellular organismal process cellular developmental process trophectodermal cell fate commitment chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching cell differentiation anatomical structure development anatomical structure formation involved in morphogenesis developmental process trophectodermal cell differentiation multicellular organismal process cellular developmental process trophectodermal cell fate commitment chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching cell differentiation anatomical structure development anatomical structure formation involved in morphogenesis cellular process cell fate commitment blastocyst development response to organic substance response to stimulus response to chemical germ-line stem cell population maintenance maintenance of cell number stem cell population maintenance regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process developmental growth growth blastocyst growth regulation of asymmetric cell division cell division asymmetric cell division regulation of cell division regulation of localization regulated exocytosis transport regulation of calcium ion-dependent exocytosis negative regulation of biological process negative regulation of transport negative regulation of regulated secretory pathway vesicle-mediated transport regulation of regulated secretory pathway localization secretion by cell regulation of secretion by cell negative regulation of secretion negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell calcium-ion regulated exocytosis secretion regulation of transport negative regulation of calcium ion-dependent exocytosis export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis regulation of exocytosis RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription response to benzoic acid response to oxygen-containing compound response to organic cyclic compound somatic stem cell population maintenance regulation of developmental process negative regulation of developmental process regulation of cell differentiation negative regulation of cell differentiation negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process formation of primary germ layer embryonic morphogenesis tissue development gastrulation cell fate commitment involved in formation of primary germ layer endoderm development endoderm formation endodermal cell fate commitment endodermal cell differentiation positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process response to retinoic acid response to lipid mesodermal cell differentiation mesoderm morphogenesis tissue morphogenesis mesodermal cell fate commitment mesoderm formation mesoderm development regulation of DNA-templated transcription initiation transcription initiation at RNA polymerase II promoter positive regulation of DNA-templated transcription initiation positive regulation of transcription initiation by RNA polymerase II DNA-templated transcription initiation regulation of transcription initiation by RNA polymerase II endodermal cell fate specification cell fate specification negative regulation of gene expression ectodermal cell fate commitment ectoderm formation ectoderm development ectodermal cell differentiation stem cell differentiation cellular response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus germ cell nucleus intracellular membrane-bounded organelle female germ cell nucleus male germ cell nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen nucleoplasm transcription repressor complex
C [auth N]	DNA (5'-D(TPCPCPAPCPAPTPTPTPGPAPAPAPGPGPCPAPAPAPTPGPGP*A)-3')	-	-	-
D [auth M]	DNA (5'-D(APTPCPCPAPTPTPTPGPCPCPTPTPTPCPAPAPAPTPGPTPGP*G)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013847	POU domain	Domain
A, B	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A, B	IPR001356	Homeodomain	Domain
A, B	IPR000327	POU-specific domain	Domain
A, B	IPR017970	Homeobox, conserved site	Conserved Site
A, B	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.