3JRV

Structure of poxvirus K7 protein in complex with RNA helicase DDX3

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8052541	3001974	SCOP2B (2022-06-29)
B	SCOP2 Family	VACV protein N1-like	8047914	4005875	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Bcl-2-like inhibitors of programmed cell death	8052541	3001974	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06227	e3jrvA1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)
B	PF06227	e3jrvB1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)
B	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06227	Poxvirus Bcl-2-like proteins (Poxv_Bcl-2-like)	Poxvirus Bcl-2-like proteins	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D, E	ATP-dependent RNA helicase DDX3X	pyrophosphatase activity ribonucleoside triphosphate phosphatase activity CTPase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA strand annealing activity RNA binding binding organic cyclic compound binding annealing activity nucleic acid binding single-stranded RNA binding pyrophosphatase activity ribonucleoside triphosphate phosphatase activity CTPase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA strand annealing activity RNA binding binding organic cyclic compound binding annealing activity nucleic acid binding single-stranded RNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding transcription factor binding protein binding mRNA binding translation initiation factor binding cell adhesion molecule binding cadherin binding catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity RNA helicase activity ATP-dependent activity, acting on RNA ATP-dependent activity RNA stem-loop binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity GTPase activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity eukaryotic initiation factor 4E binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA cytoskeletal protein binding gamma-tubulin binding tubulin binding poly(A) binding poly-purine tract binding ATP hydrolysis activity mRNA 5'-UTR binding ribonucleoprotein complex binding protein-containing complex binding ribosomal small subunit binding ribosome binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process nucleobase-containing compound metabolic process RNA secondary structure unwinding organic cyclic compound metabolic process RNA metabolic process nucleic acid metabolic process negative regulation of hydrolase activity regulation of cellular process negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cellular process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of cysteine-type endopeptidase activity regulation of biological process negative regulation of programmed cell death regulation of protein metabolic process regulation of apoptotic process negative regulation of metabolic process regulation of peptidase activity biological regulation negative regulation of molecular function regulation of macromolecule metabolic process cell death regulation of molecular function negative regulation of apoptotic process regulation of hydrolase activity negative regulation of cysteine-type endopeptidase activity apoptotic process regulation of metabolic process programmed cell death cellular response to stimulus response to stimulus positive regulation of macromolecule biosynthetic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of translation in response to stress response to endoplasmic reticulum stress positive regulation of translation in response to endoplasmic reticulum stress regulation of cellular metabolic process regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process regulation of translation in response to stress cellular response to stress positive regulation of biosynthetic process response to stress positive regulation of cellular process regulation of biosynthetic process regulation of translation in response to endoplasmic reticulum stress regulation of cellular biosynthetic process positive regulation of gene expression regulation of translation positive regulation of cellular biosynthetic process cell cycle chromosome segregation cell cycle process extrinsic apoptotic signaling pathway via death domain receptors signaling negative regulation of signaling regulation of signal transduction extrinsic apoptotic signaling pathway negative regulation of cell communication cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication regulation of apoptotic signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response toll-like receptor 7 signaling pathway regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response regulation of pattern recognition receptor signaling pathway positive regulation of defense response regulation of toll-like receptor 7 signaling pathway activation of innate immune response regulation of immune response positive regulation of toll-like receptor 7 signaling pathway activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus endolysosomal toll-like receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress positive regulation of innate immune response positive regulation of signaling negative regulation of cellular component organization protein-containing complex organization regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle regulation of cell cycle positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition toll-like receptor 8 signaling pathway positive regulation of toll-like receptor 8 signaling pathway regulation of toll-like receptor 8 signaling pathway positive regulation of viral genome replication positive regulation of viral process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication cellular response to arsenic-containing substance cellular response to chemical stimulus response to chemical response to arsenic-containing substance positive regulation of phosphorylation regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of molecular function positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation organelle organization stress granule assembly organelle assembly non-membrane-bounded organelle assembly response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus response to abiotic stimulus cellular response to abiotic stimulus regulation of protein ubiquitination positive regulation of post-translational protein modification protein K63-linked ubiquitination regulation of protein K63-linked ubiquitination protein ubiquitination regulation of protein modification by small protein conjugation or removal positive regulation of protein K63-linked ubiquitination positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of protein polyubiquitination regulation of post-translational protein modification protein polyubiquitination positive regulation of protein polyubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization localization cellular localization protein localization to cytoplasmic stress granule protein localization to organelle cellular macromolecule localization macromolecule localization protein acylation positive regulation of protein acetylation regulation of protein acetylation protein acetylation regulation of translational initiation positive regulation of translational initiation multicellular organismal process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of type I interferon production type I interferon production positive regulation of multicellular organismal process positive regulation of cytokine production regulation of type I interferon production DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process interferon-alpha production regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of cell growth positive regulation of growth chemokine (C-C motif) ligand 5 production positive regulation of chemokine (C-C motif) ligand 5 production regulation of chemokine production chemokine production positive regulation of chemokine production regulation of chemokine (C-C motif) ligand 5 production developmental process cellular developmental process cell differentiation negative regulation of cellular metabolic process negative regulation of translation negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process sexual reproduction reproductive process multicellular organismal reproductive process gamete generation intracellular signal transduction intrinsic apoptotic signaling pathway ribonucleoprotein complex biogenesis ribosome biogenesis cytosolic ribosome assembly ribosome assembly chemical homeostasis homeostatic process lipid homeostasis positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity positive regulation of endopeptidase activity positive regulation of proteolysis negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway regulation of intracellular signal transduction negative regulation of intrinsic apoptotic signaling pathway regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly inflammasome-mediated signaling pathway canonical inflammasome complex assembly positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway NLRP3 inflammasome complex assembly inflammatory response positive regulation of cellular component organization positive regulation of protein-containing complex assembly positive regulation of cellular component biogenesis regulation of non-canonical NF-kappaB signal transduction intracellular signaling cassette non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction response to virus Wnt signaling pathway regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of non-canonical NF-kappaB signal transduction protein autophosphorylation regulation of protein autophosphorylation positive regulation of protein autophosphorylation cellular response to virus	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol P granule cytoplasmic ribonucleoprotein granule germ plasm ribonucleoprotein granule intracellular organelle pole plasm intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cell periphery plasma membrane membrane membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle nucleus nucleoplasm nuclear lumen vesicle lumen cytoplasmic vesicle lumen secretory granule lumen canonical inflammasome complex protein-containing complex NLRP3 inflammasome complex
A, B	Protein K7	molecular sequestering activity protein sequestering activity	symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response response to host defenses response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus biological process involved in interaction with host symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity symbiont-mediated suppression of host signal transduction pathway modulation by symbiont of host process cellular process symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D, E	IPR011545	DEAD/DEAH box helicase domain	Domain
C, D, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, D, E	IPR001650	Helicase, C-terminal domain-like	Domain
C, D, E	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
C, D, E	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site	Conserved Site
C, D, E	IPR014014	RNA helicase, DEAD-box type, Q motif	Domain
A, B	IPR022819	Poxvirus Bcl-2-like	Family
A, B	IPR009174	Orthopoxvirus, Protein K7	Family
A, B	IPR043018	Poxvirus domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, D, E	Pharos: O00571	intellectual disability, X-linked 102 T-cell non-Hodgkin lymphoma malignant mesothelioma Neurodevelopmental Disorders intellectual disability large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma acute T cell leukemia chronic obstructive pulmonary disease dermatomyositis systemic mastocytosis gastrointestinal stromal tumor idiopathic hypereosinophilic syndrome intellectual disability, X-linked 102 T-cell non-Hodgkin lymphoma malignant mesothelioma Neurodevelopmental Disorders intellectual disability large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma acute T cell leukemia chronic obstructive pulmonary disease dermatomyositis systemic mastocytosis gastrointestinal stromal tumor idiopathic hypereosinophilic syndrome lung adenocarcinoma osteoarthritis astrocytic tumor osteosarcoma chronic eosinophilic leukemia progressive supranuclear palsy epilepsy Gaucher disease IgA glomerulonephritis interstitial lung disease lung cancer osteoarthritis susceptibility 1 atypical teratoid rhabdoid tumor ovarian cancer plasma cell myeloma dermatofibrosarcoma protuberans psoriasis Toriello-Carey syndrome hereditary spastic paraplegia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.