3IZO

Model of the fiber tail and its interactions with the penton base of human adenovirus by cryo-electron microscopy

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adeno_Penton_B_2nd	e3izoA2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: Adeno_Penton_B_2nd	ECOD (1.6)
A	Adeno_Penton_B_1st	e3izoA1	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: Adeno_Penton_B_1st	ECOD (1.6)
C [auth B]	Adeno_Penton_B_2nd	e3izoB2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: Adeno_Penton_B_2nd	ECOD (1.6)
C [auth B]	Adeno_Penton_B_1st	e3izoB1	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: Adeno_Penton_B_1st	ECOD (1.6)
E [auth C]	Adeno_Penton_B_2nd	e3izoC2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: Adeno_Penton_B_2nd	ECOD (1.6)
E [auth C]	Adeno_Penton_B_1st	e3izoC1	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: Adeno_Penton_B_1st	ECOD (1.6)
F [auth D]	Adeno_Penton_B_2nd	e3izoD2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: Adeno_Penton_B_2nd	ECOD (1.6)
F [auth D]	Adeno_Penton_B_1st	e3izoD1	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: Adeno_Penton_B_1st	ECOD (1.6)
H [auth E]	Adeno_Penton_B_2nd	e3izoE2	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: Adeno_Penton_B_2nd	ECOD (1.6)
H [auth E]	Adeno_Penton_B_1st	e3izoE1	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: Adeno_Penton_B_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.550	Mainly Beta	Sandwich	Jelly Rolls	Penton protein	CATH (4.3.0)
A	3.90.1620.10	Alpha Beta	Alpha-Beta Complex	adenovirus 2 penton base, domain 2	adenovirus 2 penton base, domain 2	CATH (4.3.0)
C [auth B]	2.60.120.550	Mainly Beta	Sandwich	Jelly Rolls	Penton protein	CATH (4.3.0)
C [auth B]	3.90.1620.10	Alpha Beta	Alpha-Beta Complex	adenovirus 2 penton base, domain 2	adenovirus 2 penton base, domain 2	CATH (4.3.0)
E [auth C]	2.60.120.550	Mainly Beta	Sandwich	Jelly Rolls	Penton protein	CATH (4.3.0)
E [auth C]	3.90.1620.10	Alpha Beta	Alpha-Beta Complex	adenovirus 2 penton base, domain 2	adenovirus 2 penton base, domain 2	CATH (4.3.0)
F [auth D]	2.60.120.550	Mainly Beta	Sandwich	Jelly Rolls	Penton protein	CATH (4.3.0)
F [auth D]	3.90.1620.10	Alpha Beta	Alpha-Beta Complex	adenovirus 2 penton base, domain 2	adenovirus 2 penton base, domain 2	CATH (4.3.0)
H [auth E]	2.60.120.550	Mainly Beta	Sandwich	Jelly Rolls	Penton protein	CATH (4.3.0)
H [auth E]	3.90.1620.10	Alpha Beta	Alpha-Beta Complex	adenovirus 2 penton base, domain 2	adenovirus 2 penton base, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], F [auth D], H [auth E]	PF01686	Adenovirus penton base protein (Adeno_Penton_B)	Adenovirus penton base protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], F [auth D], H [auth E]	Penton protein	structural molecule activity	import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis viral process symbiont entry into host import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms transport viral life cycle establishment of localization vesicle-mediated transport biological process involved in interaction with host biological process involved in symbiotic interaction localization symbiont entry into host cell clathrin-dependent endocytosis viral process symbiont entry into host cellular process clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle icosahedral viral capsid T=25 icosahedral viral capsid
B [auth F], D [auth G], G [auth H]	Fiber	-	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host adhesion receptor-mediated virion attachment to host cell cell adhesion cellular process	viral capsid virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], F [auth D], H [auth E]	IPR002605	Adenovirus penton base protein	Family
B [auth F], D [auth G], G [auth H]	IPR009013	Attachment protein shaft domain superfamily	Homologous Superfamily
B [auth F], D [auth G], G [auth H]	IPR000978	Adenoviral fibre protein, knob	Domain
B [auth F], D [auth G], G [auth H]	IPR008982	Adenovirus pIV-like, attachment domain	Homologous Superfamily
B [auth F], D [auth G], G [auth H]	IPR000931	Adenovirus fibre protein	Family
B [auth F], D [auth G], G [auth H]	IPR000939	Adenoviral fibre protein, repeat/shaft region	Repeat

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.