3IO5

Crystal Structure of a dimeric form of the uvsX Recombinase core domain from Enterobacteria Phage T4

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RecA/Rad51/KaiC-like ATPases	8056626	4004007	SCOP2 (2022-06-29)
A	SCOP2 Family	RecA C-terminal domain-like	8056628	4001163	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RecA-like P-loop NTPases	8056627	3002019	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RecA C-terminal domain-like	8056629	3000958	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8056627	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA C-terminal domain-like	8056629	3000958	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21134	e3io5A2	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: PF21134	ECOD (1.6)
A	PF00154	e3io5A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00154	ECOD (1.6)
B	PF21134	e3io5B2	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: PF21134	ECOD (1.6)
B	PF00154	e3io5B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00154	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21134	Bacteriophage T4, Recombination and repair protein, C-terminal domain (T4_UVSX_C)	Bacteriophage T4, Recombination and repair protein, C-terminal domain	This domain is mainly found in proteins from tailed bacteriophages, including Recombination and repair protein from Bacteriophage T4 (UVSX). This protein is organised into a larger N-terminal 'core' domain and a smaller C-terminal domain (this entry) ...	This domain is mainly found in proteins from tailed bacteriophages, including Recombination and repair protein from Bacteriophage T4 (UVSX). This protein is organised into a larger N-terminal 'core' domain and a smaller C-terminal domain (this entry) with mainly alpha-helical structure [1].	Domain
A, B	PF00154	recA bacterial DNA recombination protein (RecA)	recA bacterial DNA recombination protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Recombination and repair protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding single-stranded DNA binding nucleic acid binding ATP-dependent activity, acting on DNA DNA damage sensor activity catalytic activity, acting on DNA small molecule sensor activity ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress cellular process DNA repair DNA recombination	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR049047	Recombination and repair protein UVSX-like, C-terminal domain	Domain
A, B	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
A, B	IPR049428	RecA-like, N-terminal	Domain
A, B	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface	Domain
A, B	IPR013765	DNA recombination and repair protein RecA	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.