3I5S

Crystal structure of PI3K SH3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3i5sa_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3i5sb_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3i5sc_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3i5sd_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH3-domain	8041578	3000153	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SH3-domain	8041578	3000153	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SH3-domain	8041578	3000153	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SH3-domain	8041578	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e3i5sA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
B	SH3_1	e3i5sB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
C	SH3_1	e3i5sC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
D	SH3_1	e3i5sD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
B	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
C	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
D	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Phosphatidylinositol 3-kinase regulatory subunit alpha	protein binding binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity protein binding binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding protein phosphatase binding phosphatase binding enzyme binding neurotrophin TRK receptor binding neurotrophin TRKA receptor binding cytokine receptor binding neurotrophin receptor binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase activator activity insulin-like growth factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding receptor tyrosine kinase binding protein kinase binding molecular adaptor activity signaling adaptor activity signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity protein dimerization activity phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups phosphatidylinositol 3-kinase regulatory subunit binding enzyme-substrate adaptor activity ErbB-3 class receptor binding	cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance signal transduction cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of protein stability regulation of biological quality protein stabilization positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport myeloid leukocyte differentiation regulation of leukocyte differentiation multicellular organismal process cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation multicellular organism development cell differentiation osteoclast differentiation anatomical structure development negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation positive regulation of establishment of protein localization regulation of intracellular transport positive regulation of protein localization to nucleus positive regulation of protein import into nucleus regulation of nucleocytoplasmic transport regulation of intracellular protein transport positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport extrinsic apoptotic signaling pathway via death domain receptors cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus growth hormone receptor signaling pathway response to endogenous stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to organonitrogen compound cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation cellular component disassembly regulation of focal adhesion disassembly regulation of cellular component organization positive regulation of cellular component organization focal adhesion disassembly cell junction disassembly cell-substrate junction disassembly positive regulation of cell-substrate junction organization cellular component organization cell junction organization positive regulation of focal adhesion disassembly cell-substrate junction organization regulation of cell-substrate junction organization cellular component organization or biogenesis positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to stress response to stress response to endoplasmic reticulum stress B cell activation B cell differentiation immune response intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly cellular component biogenesis cellular component assembly actin filament bundle organization actin filament-based process stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly organelle organization negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process lipid metabolic process RNA processing RNA splicing regulation of RNA splicing positive regulation of gene expression positive regulation of RNA splicing positive regulation of locomotion regulation of cell motility regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of cell migration leukocyte migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility positive regulation of immune system process locomotion DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway insulin receptor signaling pathway response to insulin cellular response to insulin stimulus response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV regulation of cell-substrate adhesion regulation of cell adhesion negative regulation of cell-matrix adhesion negative regulation of cell adhesion cell-matrix adhesion regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion myeloid leukocyte migration filopodium assembly cell projection organization regulation of filopodium assembly plasma membrane bounded cell projection assembly positive regulation of cell projection organization positive regulation of filopodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway pattern recognition receptor signaling pathway regulation of signal transduction response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus regulation of toll-like receptor 4 signaling pathway regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response response to external biotic stimulus cell surface pattern recognition receptor signaling pathway regulation of signaling positive regulation of innate immune response defense response defense response to symbiont toll-like receptor 4 signaling pathway regulation of cell communication regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production cytokine production regulation of cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production positive regulation of multicellular organismal process positive regulation of cytokine production cellular response to interleukin-18 response to interleukin-18 interleukin-18-mediated signaling pathway hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport regulation of lamellipodium assembly regulation of lamellipodium organization lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization lamellipodium organization positive regulation of cell communication positive regulation of signal transduction regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress regulation of endoplasmic reticulum unfolded protein response positive regulation of response to endoplasmic reticulum stress positive regulation of endoplasmic reticulum unfolded protein response cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein positive regulation of signaling	membrane cellular anatomical entity cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex membrane cellular anatomical entity cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane membrane-bounded organelle intracellular organelle Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle endomembrane system perinuclear endoplasmic reticulum membrane organelle subcompartment endoplasmic reticulum subcompartment perinuclear endoplasmic reticulum nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cell periphery plasma membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A, B, C, D	IPR035020	PI3K p85 subunit, C-terminal SH2 domain	Domain
A, B, C, D	IPR035591	Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain	Domain
A, B, C, D	IPR032498	PI3K regulatory subunit p85-related , inter-SH2 domain	Domain
A, B, C, D	IPR001452	SH3 domain	Domain
A, B, C, D	IPR035022	PI3K p85 subunit, N-terminal SH2 domain	Domain
A, B, C, D	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B, C, D	IPR000980	SH2 domain	Domain
A, B, C, D	IPR000198	Rho GTPase-activating protein domain	Domain
A, B, C, D	IPR044124	PIK3R1, inter-SH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P27986	SHORT syndrome immunodeficiency 36 agammaglobulinemia 7, autosomal recessive Burkitt lymphoma cancer prostate cancer glioblastoma Insulin Resistance carcinoma sarcomatoid carcinoma primitive neuroectodermal tumor dermatomyositis psoriasis Gaucher disease vitiligo SHORT syndrome immunodeficiency 36 agammaglobulinemia 7, autosomal recessive Burkitt lymphoma cancer prostate cancer glioblastoma Insulin Resistance carcinoma sarcomatoid carcinoma primitive neuroectodermal tumor dermatomyositis psoriasis Gaucher disease vitiligo intellectual disability juvenile dermatomyositis agammaglobulinemia lung cancer medulloblastoma atypical teratoid rhabdoid tumor oligodendroglioma breast cancer ovarian carcinoma Pick disease colorectal adenocarcinoma ductal breast carcinoma in situ rheumatoid arthritis tuberculosis interstitial cystitis activated PI3K-delta syndrome large cell medulloblastoma mammary neoplasms, animal autosomal agammaglobulinemia osteosarcoma breast carcinoma ovarian neoplasm pituitary cancer cystic fibrosis exocrine pancreatic carcinoma glioma undifferentiated carcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant pancreatic neoplasm atrial fibrillation non-small cell lung carcinoma autosomal recessive agammaglobulinemia 1 ovarian cancer Parkinson disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.