3GYX

Crystal structure of adenylylsulfate reductase from Desulfovibrio gigas

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3gyxA2	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e3gyxA3	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00890	e3gyxA4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
C	F_UNCLASSIFIED	e3gyxC4	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e3gyxC1	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00890	e3gyxC3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
E	F_UNCLASSIFIED	e3gyxE4	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e3gyxE2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00890	e3gyxE3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
G	F_UNCLASSIFIED	e3gyxG4	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e3gyxG2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF00890	e3gyxG3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
I	F_UNCLASSIFIED	e3gyxI4	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e3gyxI2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
I	PF00890	e3gyxI3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
K	F_UNCLASSIFIED	e3gyxK4	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	F_UNCLASSIFIED	e3gyxK2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF00890	e3gyxK3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
B	PF00037,PF12139	e3gyxB1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037,PF12139	ECOD (1.6)
D	PF00037,PF12139	e3gyxD1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037,PF12139	ECOD (1.6)
F	PF00037,PF12139	e3gyxF1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037,PF12139	ECOD (1.6)
H	PF00037,PF12139	e3gyxH1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037,PF12139	ECOD (1.6)
J	PF00037,PF12139	e3gyxJ1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037,PF12139	ECOD (1.6)
L	PF00037,PF12139	e3gyxL1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037,PF12139	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
A	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
C	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
C	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
E	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
E	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
G	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
G	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
I	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
I	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
K	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)
K	3.90.700.10	Alpha Beta	Alpha-Beta Complex	Flavocytochrome C3	Chain A, domain 1	CATH (4.3.0)
B	3.30.70.20	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
B	6.20.260.10	Special	Other non-globular	Signal recognition particle alu RNA binding heterodimer, srp9/1	Adenylylsulphate reductase, beta subunit, C-terminal domain	CATH (4.3.0)
D	3.30.70.20	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
D	6.20.260.10	Special	Other non-globular	Signal recognition particle alu RNA binding heterodimer, srp9/1	Adenylylsulphate reductase, beta subunit, C-terminal domain	CATH (4.3.0)
F	3.30.70.20	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
F	6.20.260.10	Special	Other non-globular	Signal recognition particle alu RNA binding heterodimer, srp9/1	Adenylylsulphate reductase, beta subunit, C-terminal domain	CATH (4.3.0)
H	3.30.70.20	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
H	6.20.260.10	Special	Other non-globular	Signal recognition particle alu RNA binding heterodimer, srp9/1	Adenylylsulphate reductase, beta subunit, C-terminal domain	CATH (4.3.0)
J	3.30.70.20	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
J	6.20.260.10	Special	Other non-globular	Signal recognition particle alu RNA binding heterodimer, srp9/1	Adenylylsulphate reductase, beta subunit, C-terminal domain	CATH (4.3.0)
L	3.30.70.20	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
L	6.20.260.10	Special	Other non-globular	Signal recognition particle alu RNA binding heterodimer, srp9/1	Adenylylsulphate reductase, beta subunit, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K	PF00890	FAD binding domain (FAD_binding_2)	FAD binding domain	-	Family
B, D, F, H, J B, D, F, H, J, L	PF12838	4Fe-4S dicluster domain (Fer4_7)	4Fe-4S dicluster domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contai ...	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	Domain
B, D, F, H, J B, D, F, H, J, L	PF12139	Adenosine-5'-phosphosulfate reductase beta subunit (APS-reductase_C)	Adenosine-5'-phosphosulfate reductase beta subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K	Adenylylsulfate Reductase	protein heterodimerization activity protein binding binding protein dimerization activity oxidoreductase activity, acting on a sulfur group of donors oxidoreductase activity adenylyl-sulfate reductase activity catalytic activity FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding protein heterodimerization activity protein binding binding protein dimerization activity oxidoreductase activity, acting on a sulfur group of donors oxidoreductase activity adenylyl-sulfate reductase activity catalytic activity FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization cellular respiration dissimilatory sulfate reduction energy derivation by oxidation of organic compounds protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization cellular respiration dissimilatory sulfate reduction energy derivation by oxidation of organic compounds sulfate assimilation cellular metabolic process metabolic process sulfur compound metabolic process generation of precursor metabolites and energy anaerobic respiration	intracellular anatomical structure cytoplasm cellular anatomical entity
B, D, F, H, J B, D, F, H, J, L	Adenylylsulfate Reductase	protein heterodimerization activity protein binding binding protein dimerization activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization cellular respiration dissimilatory sulfate reduction energy derivation by oxidation of organic compounds protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization cellular respiration dissimilatory sulfate reduction energy derivation by oxidation of organic compounds sulfate assimilation cellular metabolic process metabolic process sulfur compound metabolic process generation of precursor metabolites and energy anaerobic respiration	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K	IPR030664	FAD-dependent oxidoreductase SdhA/FrdA/AprA	Family
A, C, E, G, I A, C, E, G, I, K	IPR037099	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR011803	Adenylylsulphate reductase, alpha subunit	Family
A, C, E, G, I A, C, E, G, I, K	IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR003953	FAD-dependent oxidoreductase 2, FAD binding domain	Domain
B, D, F, H, J B, D, F, H, J, L	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
B, D, F, H, J B, D, F, H, J, L	IPR038465	APS reductase, beta subunit, C-terminal domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L	IPR022738	Adenylylsulphate reductase, beta subunit, C-terminal	Domain
B, D, F, H, J B, D, F, H, J, L	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
B, D, F, H, J B, D, F, H, J, L	IPR011802	Adenylylsulphate reductase, beta subunit	Family

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3GYX

Crystal structure of adenylylsulfate reductase from Desulfovibrio gigas

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage