Annotations: 3GNG

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3gngA6	A: beta sandwiches	X: Major vault protein (MVP) structural repeat domain (From Topology)	H: Major vault protein (MVP) structural repeat domain (From Topology)	T: Major vault protein (MVP) structural repeat domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF01505	e3gngA3	A: beta sandwiches	X: Major vault protein (MVP) structural repeat domain (From Topology)	H: Major vault protein (MVP) structural repeat domain (From Topology)	T: Major vault protein (MVP) structural repeat domain	F: PF01505	ECOD (1.6)
A	PF17794	e3gngA4	A: beta sandwiches	X: Major vault protein (MVP) structural repeat domain (From Topology)	H: Major vault protein (MVP) structural repeat domain (From Topology)	T: Major vault protein (MVP) structural repeat domain	F: PF17794	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.570	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
A	2.30.30.560	Mainly Beta	Roll	SH3 type barrels.	Major vault protein, N-terminal structural repeat domain	CATH (4.3.0)
A	2.30.30.550	Mainly Beta	Roll	SH3 type barrels.	Major Vault Protein repeat	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01505	Major Vault Protein repeat domain (Vault)	Major Vault Protein repeat domain	The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function [1]. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.	Domain
A	PF17794	Major Vault Protein repeat domain (Vault_2)	Major Vault Protein repeat domain	This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to Pfam:PF01505.	Domain
A	PF17796	Major Vault Protein repeat domain (Vault_4)	Major Vault Protein repeat domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Major vault protein	protein binding binding kinase binding enzyme binding protein kinase binding identical protein binding protein phosphatase binding phosphatase binding	cell population proliferation cellular process regulation of cellular process regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process cell population proliferation cellular process regulation of cellular process regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process organonitrogen compound metabolic process protein phosphorylation protein autophosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of protein autophosphorylation negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation negative regulation of protein autophosphorylation regulation of metabolic process cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of ERBB signaling pathway regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of ERBB signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of cell communication protein activation cascade cellular biosynthetic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process organic substance biosynthetic process	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex ribonucleoprotein complex membrane-bounded organelle nucleus intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex ribonucleoprotein complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040989	Major vault protein repeat domain 3	Domain
A	IPR039059	Major vault protein	Family
A	IPR041136	Major vault protein repeat domain 4	Domain
A	IPR036013	Band 7/SPFH domain superfamily	Homologous Superfamily
A	IPR002499	Major vault protein, N-terminal	Repeat
A	IPR041139	Major vault protein repeat domain	Domain
A	IPR043023	Major vault protein repeat domain superfamily	Homologous Superfamily
A	IPR043179	Major vault protein repeat domain 2 superfamily	Homologous Superfamily
A	IPR021870	Major vault protein, shoulder domain	Domain
A	IPR041134	Major vault protein repeat domain 2	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.