3FEW

Structure and Function of Colicin S4, a colicin with a duplicated receptor binding domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	PF01024	e3fewX4	A: alpha arrays	X: Toxins' membrane translocation domains	H: Colicin (From Topology)	T: Colicin	F: PF01024	ECOD (1.6)
A [auth X]	F_UNCLASSIFIED	e3fewX2	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Colicin S4 receptor-binding domain (From Topology)	T: Colicin S4 receptor-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth X]	PF22512	e3fewX1	A: extended segments	X: Colicin S4 translocation domain (From Topology)	H: Colicin S4 translocation domain (From Topology)	T: Colicin S4 translocation domain	F: PF22512	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	4.10.80.380	Few Secondary Structures	Irregular	Rhinovirus 14, subunit 4		CATH (4.3.0)
A [auth X]	3.30.1310.40	Alpha Beta	2-Layer Sandwich	Ybab	Chain: A	CATH (4.3.0)
A [auth X]	1.10.490.30	Mainly Alpha	Orthogonal Bundle	Globin-like	Colicin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF01024	Colicin pore forming domain (Colicin)	Colicin pore forming domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	Colicin S4	pore-forming activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus cellular process disruption of cell in another organism biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR038283	Channel forming colicin, C-terminal domain superfamily	Homologous Superfamily
A [auth X]	IPR048582	S4-like_recptr-bd	Unknown
A [auth X]	IPR000293	Channel forming colicin, C-terminal cytotoxic	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.