3D2U

Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3d2ub_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	beta2-microglobulin	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth F]	d3d2uf_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	beta2-microglobulin	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth H]	d3d2uh1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Ligand binding domain of lir-1 (ilt2)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth D]	d3d2ud1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	Ligand binding domain of lir-1 (ilt2)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8003766	3000071	SCOP2B (2022-06-29)
E [auth F]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8003766	3000071	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055614	3000071	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054837	3000071	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055614	3000071	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054837	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07654	e3d2uA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A	PF00129	e3d2uA3	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: PF00129	ECOD (1.6)
D [auth E]	PF07654	e3d2uE3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D [auth E]	PF00129	e3d2uE4	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: PF00129	ECOD (1.6)
B	PF07654	e3d2uB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth F]	PF07654	e3d2uF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F [auth H]	F_UNCLASSIFIED	e3d2uH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth H]	PF13895	e3d2uH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)
C [auth D]	F_UNCLASSIFIED	e3d2uD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth D]	PF13895	e3d2uD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth E]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
D [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, D [auth E]	UL18	I-ALPHA-LIKE	Cytomegalovirus	UL18*01	G-DOMAIN G-ALPHA1-LIKE, G-DOMAIN G-ALPHA2-LIKE, C-LIKE-DOMAIN C-LIKE	RPI-MH1Like	MH1LIKE-ALPHA-LIKE_B2M	IMGT (202416-0)
B, E [auth F]	UL18	B2M	Cytomegalovirus	B2M01, B2M02	C-LIKE-DOMAIN C-LIKE	RPI-MH1Like	MH1LIKE-ALPHA-LIKE_B2M	IMGT (202416-0)
C [auth D], F [auth H]	LILRB1	2C-LIKE	Homo sapiens (human)	LILRB1*01	C-LIKE-DOMAIN C-LIKE	RPI	2C-LIKE	IMGT (202416-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth E]	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
A, D [auth E]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
B, E [auth F]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
C [auth D], F [auth H]	PF13895	Immunoglobulin domain (Ig_2)	Immunoglobulin domain	This domain contains immunoglobulin-like domains.	Domain
G, H [auth C]	PF00022	Actin (Actin)	Actin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth E]	UL18 protein	-	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism evasion by virus of host natural killer cell activity response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism evasion by virus of host natural killer cell activity response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process antigen processing and presentation immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport multicellular organismal process regulation of type II interferon production regulation of cellular process type II interferon production cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of type II interferon production negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process	host cellular component host cell part host cell membrane cellular anatomical entity MHC class I protein complex MHC protein complex cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex
B, E [auth F]	Beta-2-microglobulin	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding identical protein binding protein binding protein homodimerization activity protein dimerization activity structural molecule activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response regulation of cellular metabolic process immune effector process regulation of gene expression regulation of leukocyte mediated immunity regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of cellular metabolic process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process adaptive immune response regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to iron ion cellular response to chemical stimulus response to metal ion response to chemical response to iron ion cellular response to iron(III) ion response to iron(III) ion multicellular organismal-level iron ion homeostasis multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis regulation of neuron projection development regulation of cellular component organization cellular developmental process cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization system development developmental process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization positive regulation of protein binding regulation of binding positive regulation of binding regulation of protein binding positive regulation of molecular function regulation of molecular function regulation of receptor binding regulation of transferrin receptor binding positive regulation of receptor binding positive regulation of transferrin receptor binding regulation of developmental process regulation of cell differentiation regulation of cell development myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation regulation of localization import into cell positive regulation of cellular component organization transport vesicle-mediated transport localization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of transport endocytosis receptor-mediated endocytosis peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component biogenesis cellular component assembly protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly regulation of neurogenesis regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development negative regulation of multicellular organismal process positive regulation of ferrous iron binding regulation of ferrous iron binding negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of leukocyte mediated cytotoxicity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity regulation of T cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing cell killing iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport metal ion transport system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell amyloid fibril formation supramolecular fiber organization protein homotetramerization protein complex oligomerization protein tetramerization protein homooligomerization antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II negative regulation of receptor binding negative regulation of protein binding negative regulation of binding negative regulation of molecular function peptide antigen assembly with MHC class II protein complex MHC class II protein complex assembly cellular response to nicotine response to nicotine regulation of cellular senescence cellular senescence positive regulation of cellular senescence cellular response to stress response to stress antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I behavior learning or memory cognition regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion positive regulation of leukocyte activation regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of leukocyte cell-cell adhesion regulation of lymphocyte activation negative regulation of forebrain neuron differentiation forebrain development regulation of forebrain neuron differentiation central nervous system neuron differentiation head development forebrain generation of neurons animal organ development brain development central nervous system development forebrain neuron differentiation negative regulation of neuron differentiation regulation of neuron differentiation regulation of monoatomic ion transport regulation of iron ion transport regulation of metal ion transport response to organic substance biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to molecule of bacterial origin response to biotic stimulus	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex intracellular anatomical structure cytoplasm cytosol MHC class I protein complex MHC protein complex endosome membrane endosome intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome organelle membrane phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum Golgi membrane MHC class I peptide loading complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen secretory granule secretory vesicle specific granule anchoring junction cell junction focal adhesion cell-substrate junction MHC class II protein complex early endosome endosome lumen early endosome lumen recycling endosome recycling endosome membrane tertiary granule lumen tertiary granule early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
C [auth D], F [auth H]	Leukocyte immunoglobulin-like receptor subfamily B member 1	MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity inhibitory MHC class I receptor activity MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class Ib protein binding protein binding binding signaling receptor binding MHC protein binding protein phosphatase binding MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity inhibitory MHC class I receptor activity MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class Ib protein binding protein binding binding signaling receptor binding MHC protein binding protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding HLA-A specific inhibitory MHC class I receptor activity protein-containing complex binding MHC protein complex binding MHC class Ib protein complex binding SH2 domain binding protein domain specific binding identical protein binding protein homodimerization activity protein dimerization activity MHC class I protein binding	regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process transforming growth factor beta production negative regulation of macromolecule metabolic process regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process transforming growth factor beta production negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process negative regulation of transforming growth factor beta production regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte cell-cell adhesion negative regulation of cell adhesion leukocyte activation cell adhesion cell-cell adhesion T cell activation alpha-beta T cell activation regulation of immune system process regulation of cell-cell adhesion regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation negative regulation of T cell activation negative regulation of immune system process negative regulation of leukocyte cell-cell adhesion immune system process negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of alpha-beta T cell activation negative regulation of leukocyte activation regulation of lymphocyte activation cellular response to stimulus response to organic substance response to stimulus cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction regulation of leukocyte proliferation negative regulation of cell population proliferation cell population proliferation leukocyte proliferation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production tumor necrosis factor superfamily cytokine production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production negative regulation of tumor necrosis factor superfamily cytokine production immune response adaptive immune response localization import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport regulation of immune effector process cell activation involved in immune response positive regulation of cell activation positive regulation of immune response positive regulation of leukocyte activation positive regulation of immune system process positive regulation of gamma-delta T cell activation involved in immune response positive regulation of T cell activation gamma-delta T cell activation immune effector process regulation of response to stimulus regulation of immune response positive regulation of multicellular organismal process gamma-delta T cell activation involved in immune response positive regulation of biological process positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of response to stimulus regulation of gamma-delta T cell activation involved in immune response positive regulation of lymphocyte activation T cell activation involved in immune response leukocyte activation involved in immune response positive regulation of immune effector process lymphocyte activation involved in immune response positive regulation of cellular process regulation of gamma-delta T cell activation positive regulation of cell adhesion positive regulation of gamma-delta T cell activation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death negative regulation of lymphocyte proliferation negative regulation of T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell proliferation negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of immune effector process negative regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response cytokine production involved in immune response production of molecular mediator of immune response regulation of leukocyte differentiation cellular developmental process regulation of developmental process negative regulation of dendritic cell differentiation cell development mononuclear cell differentiation regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation anatomical structure development negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis negative regulation of developmental process regulation of dendritic cell differentiation negative regulation of cell development regulation of hemopoiesis dendritic cell differentiation leukocyte differentiation regulation of localization regulation of calcium ion transport regulation of transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport negative regulation of transport calcium ion transport metal ion transport negative regulation of calcium ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated immunity negative regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity negative regulation of cell killing regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of adaptive immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity negative regulation of adaptive immune response leukocyte mediated cytotoxicity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity regulation of cell killing negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity cell killing regulation of cellular component organization negative regulation of cellular component organization negative regulation of endocytosis regulation of vesicle-mediated transport cellular component organization cellular component organization or biogenesis regulation of endocytosis regulation of type II interferon production type II interferon production negative regulation of type II interferon production regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus regulation of defense response to virus defense response to virus defense response to other organism response to stress regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to external biotic stimulus response to virus regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response positive regulation of cytokine production positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response myeloid leukocyte cytokine production positive regulation of cytokine production involved in immune response macrophage cytokine production regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway immune response-inhibiting cell surface receptor signaling pathway immune response-regulating signaling pathway immune response-inhibiting signal transduction monoamine transport nitrogen compound transport organic hydroxy compound transport secretion by cell negative regulation of secretion regulation of secretion by cell signal release negative regulation of secretion by cell serotonin secretion negative regulation of serotonin secretion secretion organic substance transport cell-cell signaling export from cell serotonin transport regulation of serotonin secretion regulation of secretion skeletal system development regulation of osteoclast development system development regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation osteoclast development myeloid leukocyte differentiation regulation of osteoclast differentiation osteoclast differentiation bone cell development bone development regulation of myeloid cell differentiation animal organ development negative regulation of osteoclast differentiation negative regulation of osteoclast development myeloid cell differentiation myeloid cell development response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus response to bacterium cellular response to lipid response to molecule of bacterial origin negative regulation of type I interferon production regulation of interferon-beta production interferon-beta production type I interferon production negative regulation of interferon-beta production regulation of type I interferon production negative regulation of interleukin-10 production interleukin-10 production regulation of interleukin-10 production negative regulation of natural killer cell mediated immunity natural killer cell mediated immunity regulation of natural killer cell mediated immunity regulation of innate immune response negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus innate immune response negative regulation of innate immune response regulation of leukocyte apoptotic process dendritic cell apoptotic process negative regulation of dendritic cell apoptotic process negative regulation of programmed cell death leukocyte apoptotic process negative regulation of apoptotic process negative regulation of leukocyte apoptotic process regulation of dendritic cell apoptotic process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell regulation of interleukin-12 production negative regulation of interleukin-12 production interleukin-12 production T cell proliferation involved in immune response positive regulation of type II interferon production CD8-positive, alpha-beta T cell activation negative regulation of CD8-positive, alpha-beta T cell activation regulation of CD8-positive, alpha-beta T cell activation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm extracellular region
G, H [auth C]	Actin	hydrolase activity catalytic activity structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding hydrolase activity catalytic activity structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding tau protein binding nitric-oxide synthase binding enzyme binding identical protein binding kinesin binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding kinase binding protein kinase binding	regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition developmental process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus cellular response to nitrogen compound response to cytochalasin B response to organic substance response to endogenous stimulus response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to organic cyclic compound regulation of localization import into cell cellular localization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell regulation of endocytosis synaptic vesicle endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization endocytosis axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis system development plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development tissue morphogenesis epithelium development morphogenesis of a polarized epithelium morphogenesis of an epithelium tissue development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process organic substance metabolic process positive regulation of DNA repair cellular response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination organic cyclic compound metabolic process positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process monoamine transport norepinephrine transport nitrogen compound transport organic substance transport organic hydroxy compound transport organic cation transport catecholamine uptake catecholamine transport regulation of norepinephrine uptake norepinephrine uptake establishment or maintenance of cell polarity protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of developmental process negative regulation of biological process negative regulation of cellular process negative regulation of cell differentiation cell motility regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of cyclin-dependent protein kinase activity regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process regulation of protein kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction organization cell-cell junction assembly transepithelial transport regulation of transepithelial transport apical protein localization postsynapse organization actin cytoskeleton organization postsynaptic cytoskeleton organization postsynaptic actin cytoskeleton organization actin filament-based process synapse organization cytoskeleton organization positive regulation of norepinephrine uptake positive regulation of transport regulation of transmembrane transporter activity regulation of transporter activity transmembrane transport regulation of transmembrane transport regulation of stem cell population maintenance stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation head development animal organ development brain development substantia nigra development central nervous system development midbrain development neural nucleus development nucleotide-excision repair regulation of nucleotide-excision repair positive regulation of macromolecule biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of G0 to G1 transition G0 to G1 transition maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis protein localization to cell junction protein localization to adherens junction protein localization to cell-cell junction transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation regulation of immune system process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation immune system process regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle intracellular organelle organelle intracellular non-membrane-bounded organelle SWI/SNF superfamily-type complex brahma complex non-membrane-bounded organelle GBAF complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoskeleton actin cytoskeleton cytoplasm cytosol SWI/SNF complex cluster of actin-based cell projections brush border synapse glutamatergic synapse apical junction complex adherens junction nBAF complex axon neuron projection axon terminus presynapse distal axon calyx of Held neuron projection terminus npBAF complex polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell cortex cortical cytoskeleton cell periphery membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear matrix focal adhesion cell-substrate junction postsynapse postsynaptic cytoskeleton postsynaptic actin cytoskeleton NuA4 histone acetyltransferase complex transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex RSC-type complex dense body plasma membrane nucleosome nucleoplasm bBAF complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule blood microparticle chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome Schaffer collateral - CA1 synapse tight junction ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth E]	IPR003597	Immunoglobulin C1-set	Domain
A, D [auth E]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, D [auth E]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, D [auth E]	IPR011161	MHC class I-like antigen recognition-like	Domain
A, D [auth E]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, D [auth E]	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
B, E [auth F]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, E [auth F]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B, E [auth F]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, E [auth F]	IPR007110	Immunoglobulin-like domain	Domain
B, E [auth F]	IPR003597	Immunoglobulin C1-set	Domain
B, E [auth F]	IPR015707	Beta-2-Microglobulin	Family
C [auth D], F [auth H]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C [auth D], F [auth H]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth D], F [auth H]	IPR013151	Immunoglobulin	Domain
C [auth D], F [auth H]	IPR007110	Immunoglobulin-like domain	Domain
C [auth D], F [auth H]	IPR003599	Immunoglobulin subtype	Domain
C [auth D], F [auth H]	IPR003598	Immunoglobulin subtype 2	Domain
G, H [auth C]	IPR020902	Actin/actin-like conserved site	Conserved Site
G, H [auth C]	IPR004001	Actin, conserved site	Conserved Site
G, H [auth C]	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
G, H [auth C]	IPR004000	Actin family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, E [auth F]	Pharos: P61769	familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma acquired metabolic disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma psoriasis Sjogren syndrome glioblastoma juvenile dermatomyositis lung adenocarcinoma lymphatic system disease acute kidney failure pancreatic intraductal papillary-mucinous carcinoma periodic fever syndrome bone marrow disease Down syndrome rheumatoid arthritis subependymal giant cell astrocytoma lung cancer lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm cancer schizophrenia ulcerative colitis
C [auth D], F [auth H]	Pharos: Q8NHL6	chronic obstructive pulmonary disease head and neck cancer lung carcinoma non-small cell lung carcinoma peripheral nervous system disease psoriasis subependymal giant cell astrocytoma cutaneous lupus erythematosus interstitial cystitis MALT lymphoma osteosarcoma peripheral neuropathy schizophrenia ulcerative colitis glioblastoma chronic obstructive pulmonary disease head and neck cancer lung carcinoma non-small cell lung carcinoma peripheral nervous system disease psoriasis subependymal giant cell astrocytoma cutaneous lupus erythematosus interstitial cystitis MALT lymphoma osteosarcoma peripheral neuropathy schizophrenia ulcerative colitis glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pilocytic astrocytoma Sjogren syndrome
G, H [auth C]	Pharos: P60709	developmental malformations-deafness-dystonia syndrome coloboma dystonic disorder Baraitser-Winter cerebrofrontofacial syndrome intellectual disability Neoplasm Invasiveness Baraitser-Winter syndrome 1 carcinoma dysostosis esophageal cancer sarcomatoid carcinoma ovarian cancer central nervous system malformation large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm developmental malformations-deafness-dystonia syndrome coloboma dystonic disorder Baraitser-Winter cerebrofrontofacial syndrome intellectual disability Neoplasm Invasiveness Baraitser-Winter syndrome 1 carcinoma dysostosis esophageal cancer sarcomatoid carcinoma ovarian cancer central nervous system malformation large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm liver disease plasma cell myeloma lung disease prostate disease schizophrenia drug-induced liver injury stomach disease mammary neoplasms, animal arthritic joint disease uterine disease multiple endocrine neoplasia type 2A atypical teratoid rhabdoid tumor glioblastoma hepatocellular carcinoma obesity disorder Borst-Jadassohn intraepidermal carcinoma ovarian disease cerebrovascular disorder colonic disease linear and whorled nevoid hypermelanosis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia coronary artery disease lung adenocarcinoma primary cutaneous amyloidosis craniosynostosis rheumatoid arthritis malignant ependymoma seborrheic keratosis malignant pancreatic neoplasm skin basal cell carcinoma type 2 diabetes mellitus astrocytic tumor vertebral column disease mycosis fungoides autoimmune disease head and neck cancer neoplasm of esophagus Becker nevus syndrome hyperglycemia osteoarthritis breast disease osteosarcoma kidney disease pancreatic ductal adenocarcinoma chronic obstructive pulmonary disease pilocytic astrocytoma lung benign neoplasm primitive neuroectodermal tumor dermatomyositis lymphatic system disease Down syndrome malignant glioma skin disease undifferentiated carcinoma medulloblastoma atherosclerosis X-linked mixed deafness with perilymphatic gusher eye disease myocardial ischemia hematologic disease neurodegenerative disease bipolar disorder hypertensive disorder osteoarthritis susceptibility 1 cancer