Annotations: 2VXP

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fasciclin	e2vxpA2	A: beta barrels	X: Ribosomal protein L25-like	H: FAS1 domain (From Topology)	T: FAS1 domain	F: Fasciclin	ECOD (1.6)
B	Fasciclin	e2vxpB1	A: beta barrels	X: Ribosomal protein L25-like	H: FAS1 domain (From Topology)	T: FAS1 domain	F: Fasciclin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.180.10	Mainly Beta	Roll	FAS1 domain	FAS1 domain	CATH (4.3.0)
B	2.30.180.10	Mainly Beta	Roll	FAS1 domain	FAS1 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02469	Fasciclin domain (Fasciclin)	Fasciclin domain	This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TRANSFORMING GROWTH FACTOR-BETA-INDUCED PROTEIN IG-H3	extracellular matrix binding binding cell adhesion molecule binding protein binding collagen binding protein-containing complex binding integrin binding signaling receptor binding structural molecule activity extracellular matrix structural constituent identical protein binding	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development localization cell population proliferation cellular process cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization response to stimulus cell adhesion sensory perception of light stimulus system process sensory perception nervous system process visual perception cellular developmental process connective tissue development animal organ development tissue development skeletal system development cell differentiation chondrocyte differentiation cartilage development regulation of biological process regulation of cellular process regulation of cell adhesion negative regulation of cellular process biological regulation negative regulation of biological process negative regulation of cell adhesion	basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle plasma membrane membrane intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle trans-Golgi network cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036378	FAS1 domain superfamily	Homologous Superfamily
A, B	IPR016666	TGF beta-induced protein/periostin	Family
A, B	IPR011489	EMI domain	Domain
A, B	IPR000782	FAS1 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q15582	granular corneal dystrophy type II Reis-Bucklers corneal dystrophy Thiel-Behnke corneal dystrophy granular corneal dystrophy type I epithelial basement membrane dystrophy lattice corneal dystrophy type I corneal dystrophy, lattice type 3A lattice corneal dystrophy Sepsis amyloidosis gastric carcinoma interstitial lung disease ulcerative colitis large cell medulloblastoma limb-girdle muscular dystrophy granular corneal dystrophy type II Reis-Bucklers corneal dystrophy Thiel-Behnke corneal dystrophy granular corneal dystrophy type I epithelial basement membrane dystrophy lattice corneal dystrophy type I corneal dystrophy, lattice type 3A lattice corneal dystrophy Sepsis amyloidosis gastric carcinoma interstitial lung disease ulcerative colitis large cell medulloblastoma limb-girdle muscular dystrophy malignant colon neoplasm acquired metabolic disease malignant mesothelioma B-cell chronic lymphocytic leukemia corneal dystrophy corneal granular dystrophy pancreatic ductal adenocarcinoma pilocytic astrocytoma gelatinous drop-like corneal dystrophy subependymal giant cell astrocytoma juvenile dermatomyositis lung cancer malignant ependymoma malignant pancreatic neoplasm Becker muscular dystrophy oligodendroglioma Crohn disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Duchenne muscular dystrophy pituitary cancer esophageal adenocarcinoma glioblastoma IgA glomerulonephritis keratoconus lung carcinoma malignant glioma atypical teratoid rhabdoid tumor medulloblastoma corneal deposit ovarian cancer diabetic kidney disease Pick disease endometriosis psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.