Annotations: 2VRS

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Virus attachment protein globular domain	8092993	3001376	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Fibre shaft of virus attachment proteins	8092995	3001872	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibre shaft of virus attachment proteins	8092995	3001872	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Virus attachment protein globular domain	8092993	3001376	SCOP2B (2022-06-29)
B	SCOP2 Family	Reovirus sigma C capsid protein C-terminal domain-like	8046163	4004920	SCOP2 (2022-06-29)
B	SCOP2 Family	Reovirus sigma C capsid protein shaft	8092994	4007788	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Virus attachment protein globular domain	8092993	3001376	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Fibre shaft of virus attachment proteins	8092995	3001872	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Reo_sigmaC_2nd	e2vrsA2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Reo_sigmaC_2nd	ECOD (1.6)
A	Reo_sigmaC_1st_1	e2vrsA1	A: beta duplicates or obligate multimers	X: Triple beta-spiral (From Topology)	H: Triple beta-spiral (From Topology)	T: Triple beta-spiral	F: Reo_sigmaC_1st_1	ECOD (1.6)
C	Reo_sigmaC_2nd	e2vrsC2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Reo_sigmaC_2nd	ECOD (1.6)
C	Reo_sigmaC_1st_1	e2vrsC1	A: beta duplicates or obligate multimers	X: Triple beta-spiral (From Topology)	H: Triple beta-spiral (From Topology)	T: Triple beta-spiral	F: Reo_sigmaC_1st_1	ECOD (1.6)
B	Reo_sigmaC_2nd	e2vrsB2	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Reo_sigmaC_2nd	ECOD (1.6)
B	Reo_sigmaC_1st_1	e2vrsB1	A: beta duplicates or obligate multimers	X: Triple beta-spiral (From Topology)	H: Triple beta-spiral (From Topology)	T: Triple beta-spiral	F: Reo_sigmaC_1st_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	2.10.25.20	Mainly Beta	Ribbon	Laminin	reovirus attachment protein sigma1	CATH (4.3.0)
A	2.60.90.40	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)		CATH (4.3.0)
C	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	2.10.25.20	Mainly Beta	Ribbon	Laminin	reovirus attachment protein sigma1	CATH (4.3.0)
C	2.60.90.40	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)		CATH (4.3.0)
B	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	2.10.25.20	Mainly Beta	Ribbon	Laminin	reovirus attachment protein sigma1	CATH (4.3.0)
B	2.60.90.40	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF17750	Reovirus sigma C capsid protein triple beta spiral (Reo_sigmaC_M)	Reovirus sigma C capsid protein triple beta spiral	-	Family
A, B, C	PF04582	Reovirus sigma C capsid protein C-terminal domain (Reo_sigmaC)	Reovirus sigma C capsid protein C-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	SIGMA-C CAPSID PROTEIN	-	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host	viral capsid virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR041345	Reovirus sigma C capsid protein triple beta spiral	Domain
A, B, C	IPR007662	Reovirus sigma C capsid protein, C-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.