2VOP
Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2vopa1 | All alpha proteins | DNA/RNA-binding 3-helical bundle | 'Winged helix' DNA-binding domain | La domain | Lupus La autoantigen N-terminal domain | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d2vopa2 | Alpha and beta proteins (a+b) | Ferredoxin-like | RNA-binding domain, RBD, aka RNA recognition motif (RRM) | Canonical RBD | Lupus LA protein | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF05383 | e2vopA1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF05383 | ECOD (1.6) |
A | PF00076 | e2vopA2 | A: a+b two layers | X: Alpha-beta plaits | H: RNA-binding domain, RBD (From Topology) | T: RNA-binding domain, RBD | F: PF00076 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.10.10 | Mainly Alpha | Orthogonal Bundle | Arc Repressor Mutant, subunit A | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | CATH (4.3.0) |
A | 3.30.70.330 | Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | RRM (RNA recognition motif) domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF05383 | La domain (La) | La domain | This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins [1]. The function of this region is uncertain. | Domain | |
PF00076 | RNA recognition motif (RRM_1) | RNA recognition motif | The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ... | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR002344 | Lupus La protein | Family | |
IPR006630 | La-type HTH domain | Domain | |
IPR014886 | La protein, xRRM domain | Domain | |
IPR000504 | RNA recognition motif domain | Domain | |
IPR036388 | Winged helix-like DNA-binding domain superfamily | Homologous Superfamily | |
IPR036390 | Winged helix DNA-binding domain superfamily | Homologous Superfamily | |
IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily | Homologous Superfamily | |
IPR045180 | La domain containing protein | Family | |
IPR035979 | RNA-binding domain superfamily | Homologous Superfamily |