2TOH

TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2toha_	Alpha and beta proteins (a+b)	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	Tyrosine hydroxylase	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Aromatic aminoacid monoxygenases catalytic and oligomerization domains	8024888	4002591	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aromatic aminoacid monoxygenases catalytic and oligomerization domains	8037267	3001457	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Biopterin_H	e2tohA1	A: a+b complex topology	X: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains (From Topology)	H: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains (From Topology)	T: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	F: Biopterin_H	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.800.10	Mainly Alpha	Orthogonal Bundle	Phenylalanine Hydroxylase	Aromatic amino acid hydroxylase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00351	Biopterin-dependent aromatic amino acid hydroxylase (Biopterin_H)	Biopterin-dependent aromatic amino acid hydroxylase	This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TYROSINE 3-MONOOXYGENASE	binding amino acid binding cation binding ion binding catecholamine binding organic cyclic compound binding dopamine binding small molecule binding protein binding protein domain specific binding oxygen binding transition metal ion binding iron ion binding ferrous iron binding binding amino acid binding cation binding ion binding catecholamine binding organic cyclic compound binding dopamine binding small molecule binding protein binding protein domain specific binding oxygen binding transition metal ion binding iron ion binding ferrous iron binding metal ion binding monooxygenase activity oxidoreductase activity catalytic activity identical protein binding ferric iron binding tetrahydrobiopterin binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen tyrosine 3-monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen enzyme binding	response to stimulus response to chemical response to xenobiotic stimulus heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction response to stimulus response to chemical response to xenobiotic stimulus heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development epinephrine biosynthetic process organonitrogen compound metabolic process organic hydroxy compound metabolic process organonitrogen compound biosynthetic process catechol-containing compound metabolic process organic cyclic compound metabolic process amine metabolic process biogenic amine biosynthetic process organic substance metabolic process biosynthetic process epinephrine metabolic process catecholamine metabolic process amine biosynthetic process phenol-containing compound metabolic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process catecholamine biosynthetic process organic substance biosynthetic process phenol-containing compound biosynthetic process metabolic process catechol-containing compound biosynthetic process biogenic amine metabolic process oxoacid metabolic process dopamine metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process dopamine biosynthetic process small molecule metabolic process tyrosine metabolic process dopamine biosynthetic process from tyrosine erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process cellular process behavior learning or memory nervous system process cognition memory response to organic substance response to ketone response to lipid response to endogenous stimulus response to alcohol response to glucocorticoid response to oxygen-containing compound response to corticosterone response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone response to organic cyclic compound response to metal ion response to zinc ion response to inorganic substance membrane lipid metabolic process cellular lipid metabolic process sphingolipid metabolic process lipid metabolic process response to insecticide response to toxic substance cellular localization nitrogen compound transport transport organic substance transport synaptic vesicle cycle neurotransmitter transport establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse amine transport localization aminergic neurotransmitter loading into synaptic vesicle neurotransmitter loading into synaptic vesicle establishment of localization in cell cellular response to stimulus cellular response to chemical stimulus cellular response to xenobiotic stimulus alkaloid metabolic process isoquinoline alkaloid metabolic process response to osmotic stress response to stress response to abiotic stimulus response to salt stress phytoalexin metabolic process toxin metabolic process secondary metabolic process response to ether terpene metabolic process hydrocarbon metabolic process isoprenoid metabolic process phthalate metabolic process benzene-containing compound metabolic process homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis response to activity eating behavior feeding behavior cellular developmental process sensory organ development photoreceptor cell differentiation visual system development cell development eye morphogenesis neurogenesis neuron differentiation cell differentiation eye photoreceptor cell differentiation animal organ morphogenesis sensory system development photoreceptor cell development eye photoreceptor cell development eye development nervous system development generation of neurons anatomical structure morphogenesis sensory organ morphogenesis neuron development cellular response to inorganic substance cellular response to metal ion cellular response to manganese ion response to manganese ion fatty acid metabolic process monocarboxylic acid metabolic process cellular response to nicotine response to nicotine cellular response to endogenous stimulus cellular response to growth factor stimulus response to growth factor response to immobilization stress response to isolation stress biological process involved in intraspecies interaction between organisms social behavior response to amine response to organonitrogen compound response to nitrogen compound response to amphetamine biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin response to estradiol learning reproductive process multicellular organismal reproductive process reproductive behavior mating behavior response to light stimulus response to radiation norepinephrine biosynthetic process norepinephrine metabolic process cellular response to nitrogen compound response to alkaloid cellular response to organonitrogen compound cellular response to alkaloid response to electrical stimulus head development forebrain development brain development pallium development cerebral cortex development central nervous system development telencephalon development trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling synaptic transmission, dopaminergic response to decreased oxygen levels response to hypoxia response to oxygen levels embryonic eye morphogenesis embryo development embryonic camera-type eye development embryonic organ development embryonic organ morphogenesis camera-type eye morphogenesis embryonic morphogenesis embryonic camera-type eye morphogenesis camera-type eye development response to nutrient levels locomotory behavior response to peptide hormone glycosyl compound metabolic process glycoside metabolic process carbohydrate derivative metabolic process anatomical structure regression hyaloid vascular plexus regression rhythmic process circadian sleep/wake cycle circadian behavior rhythmic behavior circadian rhythm response to ethanol response to herbicide sensory perception of light stimulus sensory perception visual perception response to pyrethroid	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum smooth endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum smooth endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system transport vesicle synapse intracellular vesicle presynapse cytoplasmic vesicle synaptic vesicle cell junction secretory vesicle vesicle exocytic vesicle pigment granule membrane chitosome melanosome cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane melanosome membrane organelle membrane pigment granule membrane cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection perinuclear region of cytoplasm axon mitochondrion axon terminus distal axon terminal bouton neuron projection terminus cell periphery cytoplasmic side of plasma membrane cytoplasmic side of membrane plasma membrane side of membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005962	Tyrosine 3-monooxygenase	Family
A	IPR019773	Tyrosine 3-monooxygenase-like	Family
A	IPR049321	Tyrosine 3-monooxygenase-like, ACT domain	Domain
A	IPR036329	Aromatic amino acid monoxygenase, C-terminal domain superfamily	Homologous Superfamily
A	IPR045865	ACT-like domain	Homologous Superfamily
A	IPR041903	Tyrosine 3-monooxygenase, catalytic domain	Domain
A	IPR018301	Aromatic amino acid hydroxylase, iron/copper binding site	Binding Site
A	IPR021164	Tyrosine hydroxylase, conserved site	Conserved Site
A	IPR019774	Aromatic amino acid hydroxylase, C-terminal	Domain
A	IPR036951	Aromatic amino acid hydroxylase superfamily	Homologous Superfamily
A	IPR001273	Aromatic amino acid hydroxylase	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	tyrosine 3-monooxygenase M-CSA #134	Tyrosine hydroxylase, sourced from Rattus norvegicus belongs to a family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It catalyses the hydroxylation of the aromatic group of tyrosine. Tyrosine hydroxylase is found in the central nervous system and the adrenal gland where it's role is to catalyse the production of dihydroxyphenylalanine (DOPA) - the rate limiting step in the biosynthesis of catecholamine neurotransmitters.	Defined by 4 residues: HIS:A-176 [auth A-331]HIS:A-181 [auth A-336]GLU:A-221 [auth A-376]SER:A-240 [auth A-395] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.14.16.2 (PDB Primary Data) Search M-CSA Motif + EC 1.14.16.2

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.