Annotations: 2RGK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2rgka_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	N-acylglucosamine (NAG) epimerase	Putative NAG isomerase YihS	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2rgkb_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	N-acylglucosamine (NAG) epimerase	Putative NAG isomerase YihS	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2rgkc_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	N-acylglucosamine (NAG) epimerase	Putative NAG isomerase YihS	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d2rgkd_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	N-acylglucosamine (NAG) epimerase	Putative NAG isomerase YihS	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d2rgke_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	N-acylglucosamine (NAG) epimerase	Putative NAG isomerase YihS	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d2rgkf_	All alpha proteins	alpha/alpha toroid	Six-hairpin glycosidases	N-acylglucosamine (NAG) epimerase	Putative NAG isomerase YihS	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	N-acylglucosamine (NAG) epimerase	8087653	4001174	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Six-hairpin glycosidases	8087654	3000970	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Six-hairpin glycosidases	8087654	3000970	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Six-hairpin glycosidases	8087654	3000970	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Six-hairpin glycosidases	8087654	3000970	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Six-hairpin glycosidases	8087654	3000970	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Six-hairpin glycosidases	8087654	3000970	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07221	e2rgkA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF07221	ECOD (1.6)
B	PF07221	e2rgkB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF07221	ECOD (1.6)
C	PF07221	e2rgkC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF07221	ECOD (1.6)
D	PF07221	e2rgkD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF07221	ECOD (1.6)
E	PF07221	e2rgkE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF07221	ECOD (1.6)
F	PF07221	e2rgkF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF07221	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
B	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
C	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
D	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
E	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
F	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF07221	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) (GlcNAc_2-epim)	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Uncharacterized sugar isomerase yihS	isomerase activity sulfoquinovose isomerase activity catalytic activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity mannose isomerase activity identical protein binding protein binding binding	carbohydrate derivative catabolic process catabolic process cellular metabolic process carbohydrate derivative metabolic process 6-sulfoquinovose(1-) catabolic process organic acid catabolic process organic acid metabolic process cellular catabolic process sulfur compound catabolic process 6-sulfoquinovose(1-) metabolic process organic substance metabolic process sulfur compound metabolic process metabolic process cellular process carbohydrate derivative catabolic process catabolic process cellular metabolic process carbohydrate derivative metabolic process 6-sulfoquinovose(1-) catabolic process organic acid catabolic process organic acid metabolic process cellular catabolic process sulfur compound catabolic process 6-sulfoquinovose(1-) metabolic process organic substance metabolic process sulfur compound metabolic process metabolic process cellular process small molecule metabolic process small molecule catabolic process organic substance catabolic process carbohydrate metabolic process primary metabolic process organic hydroxy compound metabolic process alcohol metabolic process cellular ketone metabolic process cellular aldehyde metabolic process phosphate-containing compound metabolic process phosphorus metabolic process 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde secondary alcohol metabolic process organophosphate metabolic process alkanesulfonate metabolic process primary alcohol metabolic process cellular component organization cellular component biogenesis protein hexamerization cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular component organization or biogenesis	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR012341	Six-hairpin glycosidase-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR010819	N-acylglucosamine 2-epimerase/Cellobiose 2-epimerase	Family
A, B, C, D, E A, B, C, D, E, F	IPR030875	Sulfoquinovose isomerase	Family
A, B, C, D, E A, B, C, D, E, F	IPR034116	AGE domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.