Annotations: 2R94

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth D]	d2r94d_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	automated matches	automated matches	(Thermoproteus tenax ) [TaxId: 2271 ],	SCOPe (2.08)
A	d2r94a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	automated matches	automated matches	(Thermoproteus tenax ) [TaxId: 2271 ],	SCOPe (2.08)
C [auth B]	d2r94b_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	automated matches	automated matches	(Thermoproteus tenax ) [TaxId: 2271 ],	SCOPe (2.08)
D [auth C]	d2r94c_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	automated matches	automated matches	(Thermoproteus tenax ) [TaxId: 2271 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth D]	SCOP2 Family	Class I aldolase	8059182	4003216	SCOP2 (2022-06-29)
B [auth D]	SCOP2 Superfamily	Aldolase	8059183	3000445	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Aldolase	8059183	3000445	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Aldolase	8059183	3000445	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Aldolase	8059183	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth D]	PF00701	e2r94D1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00701	ECOD (1.6)
A	PF00701	e2r94A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00701	ECOD (1.6)
C [auth B]	PF00701	e2r94B1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00701	ECOD (1.6)
D [auth C]	PF00701	e2r94C1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00701	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth D]	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C [auth B]	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D [auth C]	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth B], D [auth C]	PF00701	Dihydrodipicolinate synthetase family (DHDPS)	Dihydrodipicolinate synthetase family	This family has a TIM barrel structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth B], D [auth C]	2-Keto-3-deoxy-(6-phospho-)gluconate aldolase	4-hydroxy-tetrahydrodipicolinate synthase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity 2-dehydro-3-deoxy-phosphogluconate aldolase activity carbon-carbon lyase activity aldehyde-lyase activity oxo-acid-lyase activity 4-hydroxy-2-oxoglutarate aldolase activity 2-dehydro-3-deoxy-D-gluconate aldolase activity	glyoxylate metabolic process catabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process cellular catabolic process organic substance metabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process glyoxylate catabolic process cellular aldehyde metabolic process metabolic process glyoxylate metabolic process catabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process cellular catabolic process organic substance metabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process glyoxylate catabolic process cellular aldehyde metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process aldehyde catabolic process small molecule catabolic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth B], D [auth C]	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B [auth D], C [auth B], D [auth C]	IPR002220	DapA-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.