2PK2

Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2pk2a1	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	Cyclin T1	human, (Homo sapiens ) [TaxId: 9606 ], human, (Equine infectious anemia virus ) [TaxId: 11665 ],	SCOPe (2.08)
B	d2pk2b1	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	Cyclin T1	human, (Homo sapiens ) [TaxId: 9606 ], human, (Equine infectious anemia virus ) [TaxId: 11665 ],	SCOPe (2.08)
C	d2pk2c1	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	Cyclin T1	human, (Homo sapiens ) [TaxId: 9606 ], human, (Equine infectious anemia virus ) [TaxId: 11665 ],	SCOPe (2.08)
D	d2pk2d1	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	Cyclin T1	human, (Homo sapiens ) [TaxId: 9606 ], human, (Equine infectious anemia virus ) [TaxId: 11665 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cyclin-like	8039364	3000768	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cyclin-like	8039367	3000768	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cyclin-like	8039367	3000768	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cyclin-like	8039364	3000768	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cyclin-like	8039364	3000768	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cyclin-like	8039367	3000768	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cyclin-like	8039367	3000768	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cyclin-like	8039364	3000768	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00134	e2pk2A1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF00134	ECOD (1.6)
A	PF21797	e2pk2A2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF21797	ECOD (1.6)
B	PF00134	e2pk2B1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF00134	ECOD (1.6)
B	PF21797	e2pk2B2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF21797	ECOD (1.6)
C	PF00134	e2pk2C1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF00134	ECOD (1.6)
C	PF21797	e2pk2C2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF21797	ECOD (1.6)
D	PF00134	e2pk2D1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF00134	ECOD (1.6)
D	PF21797	e2pk2D2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF21797	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
B	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
C	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
D	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00134	Cyclin, N-terminal domain (Cyclin_N)	Cyclin, N-terminal domain	Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.	Domain
A, B, C, D	PF21797	Cyclin-T2-like, C-terminal domain (CycT2-like_C)	Cyclin-T2-like, C-terminal domain	This domain is found at the C-terminal end of human Cyclin-T2 (CycT2) and similar animal sequences. CycT2 is the regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P ...	This domain is found at the C-terminal end of human Cyclin-T2 (CycT2) and similar animal sequences. CycT2 is the regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB). This domain adopts s cyclin box fold consisting of five helices and a short C-terminal helix [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Cyclin-T1, Protein Tat	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity RNA polymerase binding protein binding enzyme binding RNA binding snRNA binding 7SK snRNA binding cyclin-dependent protein serine/threonine kinase activator activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity cyclin-dependent protein serine/threonine kinase regulator activity molecular function regulator activity protein kinase activator activity kinase regulator activity kinase binding protein kinase binding transcription factor binding DNA-binding transcription factor binding transcription regulator activity RNA-binding transcription regulator activity	response to stimulus response to chemical response to xenobiotic stimulus regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of DNA-templated transcription elongation response to stimulus response to chemical response to xenobiotic stimulus regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of DNA-templated transcription elongation regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of DNA-templated transcription, elongation positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process DNA-templated transcription elongation positive regulation of RNA biosynthetic process cellular process positive regulation of cellular biosynthetic process cell division transcription by RNA polymerase II cell cycle viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction regulation of transcription by RNA polymerase II regulation of transcription elongation by RNA polymerase II positive regulation of transcription by RNA polymerase II transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of cyclin-dependent protein kinase activity regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process regulation of cell cycle organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of protein kinase activity regulation of molecular function regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process regulation of viral process regulation of viral transcription positive regulation of viral process positive regulation of viral transcription	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen protein kinase complex intracellular organelle nucleoplasm catalytic complex cyclin/CDK positive transcription elongation factor complex membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen protein kinase complex intracellular organelle nucleoplasm catalytic complex cyclin/CDK positive transcription elongation factor complex cyclin-dependent protein kinase holoenzyme complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex, transferring phosphorus-containing groups organelle lumen carboxy-terminal domain protein kinase complex organelle serine/threonine protein kinase complex nuclear cyclin-dependent protein kinase holoenzyme complex nuclear lumen cytoplasm cytosol P-TEFb complex host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region host cell nucleus host cell nucleolus host cell nuclear part host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR047320	Cyclin-T1, second cyclin box	Domain
A, B, C, D	IPR006671	Cyclin, N-terminal	Domain
A, B, C, D	IPR036915	Cyclin-like superfamily	Homologous Superfamily
A, B, C, D	IPR043198	Cyclin/Cyclin-like subunit Ssn8	Family
A, B, C, D	IPR013763	Cyclin-like domain	Domain
A, B, C, D	IPR001831	Immunodeficiency virus transactivating regulatory protein (Tat)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: O60563	acute myeloid leukemia osteosarcoma Pick disease juvenile dermatomyositis ovarian cancer psoriasis myopathy pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.