Annotations: 2P6S

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2p6sa1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
A	d2p6sa2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
B	d2p6sb1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
B	d2p6sb2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
C	d2p6sc1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
C	d2p6sc2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
D	d2p6sd1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
D	d2p6sd2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
E	d2p6se1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
E	d2p6se2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
F	d2p6sf1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
F	d2p6sf2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
G	d2p6sg1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
G	d2p6sg2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
H	d2p6sh1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)
H	d2p6sh2	Alpha and beta proteins (a+b)	Ferredoxin-like	Dimeric alpha+beta barrel	automated matches	automated matches	(Neisseria meningitidis MC58 ) [TaxId: 122586 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13412	e2p6sA1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
A	PF01037	e2p6sA2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
B	PF13412	e2p6sB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
B	PF01037	e2p6sB2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
C	PF13412	e2p6sC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
C	PF01037	e2p6sC2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
D	PF13412	e2p6sD1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
D	PF01037	e2p6sD2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
E	PF13412	e2p6sE1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
E	PF01037	e2p6sE2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
F	PF13412	e2p6sF1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
F	PF01037	e2p6sF2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
G	PF13412	e2p6sG1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
G	PF01037	e2p6sG2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)
H	PF13412	e2p6sH1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13412	ECOD (1.6)
H	PF01037	e2p6sH2	A: a+b two layers	X: Alpha-beta plaits	H: Dimeric alpha+beta barrel (From Topology)	T: Dimeric alpha+beta barrel	F: PF01037	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
A	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
C	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
C	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
D	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
D	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
E	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
E	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
F	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
F	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
G	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
G	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)
H	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
H	3.30.70.920	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF01037	Lrp/AsnC ligand binding domain (AsnC_trans_reg)	Lrp/AsnC ligand binding domain	The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to ...	The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold [2]. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF13412	Winged helix-turn-helix DNA-binding (HTH_24)	Winged helix-turn-helix DNA-binding	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Transcriptional regulator, LRP/AsnC family	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	response to acid chemical response to organic substance response to stimulus response to chemical response to amino acid	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR019885	Transcription regulator HTH, AsnC-type, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011991	ArsR-like helix-turn-helix domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR019887	Transcription regulator AsnC/Lrp, ligand binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000485	AsnC-type HTH domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011008	Dimeric alpha-beta barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR019888	Transcription regulator AsnC-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.