2O2F

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ABcl-2e2o2fA1 A: alpha arraysX: Toxins' membrane translocation domainsH: Bcl-2 inhibitors of programmed cell death (From Topology)T: Bcl-2 inhibitors of programmed cell deathF: Bcl-2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-likeCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02180Bcl-2 homology region 4 (BH4)Bcl-2 homology region 4- Family
PF00452Apoptosis regulator proteins, Bcl-2 family (Bcl-2)Apoptosis regulator proteins, Bcl-2 family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Apoptosis regulator Bcl-2

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP10415