2M6I

Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02932	e2m6iA1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: PF02932	ECOD (1.6)
B	PF02932	e2m6iB1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: PF02932	ECOD (1.6)
C	PF02932	e2m6iC1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: PF02932	ECOD (1.6)
D	PF02932	e2m6iD1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: PF02932	ECOD (1.6)
E	PF02932	e2m6iE1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: PF02932	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit	monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity extracellularly glycine-gated ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity extracellularly glycine-gated ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity extracellularly glycine-gated chloride channel activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity binding organic acid binding ion binding anion binding alkanesulfonate binding taurine binding sulfur compound binding small molecule binding cation binding glycine binding amino acid binding carboxylic acid binding identical protein binding protein binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential transmitter-gated channel activity transition metal ion binding zinc ion binding metal ion binding	multicellular organismal process regulation of biological process system process negative regulation of nervous system process regulation of cellular process nervous system process regulation of system process biological regulation negative regulation of biological process transmission of nerve impulse negative regulation of transmission of nerve impulse negative regulation of cell communication cell communication regulation of nervous system process regulation of transmission of nerve impulse multicellular organismal process regulation of biological process system process negative regulation of nervous system process regulation of cellular process nervous system process regulation of system process biological regulation negative regulation of biological process transmission of nerve impulse negative regulation of transmission of nerve impulse negative regulation of cell communication cell communication regulation of nervous system process regulation of transmission of nerve impulse negative regulation of cellular process regulation of cell communication cellular process regulation of multicellular organismal process negative regulation of multicellular organismal process transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport startle response response to stimulus neuromuscular process response to external stimulus sexual reproduction regulation of reproductive process reproductive process fertilization positive regulation of biological process positive regulation of acrosome reaction acrosome reaction regulation of acrosome reaction single fertilization positive regulation of reproductive process regulation of biological quality regulation of membrane potential cellular response to acid chemical cellular response to stimulus cellular response to amino acid stimulus response to acid chemical response to organic substance cellular response to chemical stimulus response to chemical response to amino acid response to alcohol response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to alcohol cellular response to organic substance cellular response to ethanol response to ethanol regulation of postsynaptic membrane potential signaling chemical synaptic transmission, postsynaptic synaptic signaling signal transduction trans-synaptic signaling cell surface receptor signaling pathway cell-cell signaling chemical synaptic transmission anterograde trans-synaptic signaling inhibitory postsynaptic potential neuromuscular process controlling posture muscle contraction muscle system process adult walking behavior adult locomotory behavior behavior adult behavior locomotory behavior walking behavior G protein-coupled receptor signaling pathway neuropeptide signaling pathway synaptic transmission, glycinergic reflex righting reflex respiratory gaseous exchange by respiratory system respiratory system process regulation of respiratory gaseous exchange regulation of respiratory system process regulation of respiratory gaseous exchange by nervous system process action potential neuronal action potential cellular response to inorganic substance cellular response to metal ion response to zinc ion response to inorganic substance response to metal ion cellular response to zinc ion sensory perception of light stimulus sensory perception visual perception	protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex cell periphery postsynapse postsynaptic membrane synapse cell junction plasma membrane protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex cell periphery postsynapse postsynaptic membrane synapse cell junction plasma membrane plasma membrane region synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body cell surface external side of plasma membrane side of membrane cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection inhibitory synapse glycinergic synapse membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha	Family
A, B, C, D, E	IPR008127	Glycine receptor alpha	Family
A, B, C, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, B, C, D, E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B, C, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B, C, D, E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, B, C, D, E	IPR008128	Glycine receptor alpha1	Family
A, B, C, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: P23415	hyperekplexia 1 hereditary hyperekplexia Idiopathic familial dystonia generalized dystonia intellectual disability dystonic disorder focal dystonia

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E	OPM	Transmembrane	Alpha-helical polytopic	Pentameric ligand-gated ion channels	Ligand-gated ion channel of neurotransmitter receptors

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Cys-Loop Receptor Family	Human glycine receptor (hGlyR-α1) transmembrane domain monomer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.