Annotations: 2KEF

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF06446	Hepcidin (Hepcidin)	Hepcidin	Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of ...	Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hepcidin	cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding hormone activity protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding hormone activity protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of macrophage activation multicellular organismal process regulation of biological process positive regulation of macrophage activation intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of macrophage activation multicellular organismal process regulation of biological process positive regulation of macrophage activation regulation of cellular process regulation of leukocyte activation cell activation biological regulation positive regulation of biological process regulation of cell activation myeloid leukocyte activation leukocyte activation macrophage activation positive regulation of cell activation immune system process positive regulation of leukocyte activation positive regulation of multicellular organismal process cellular process regulation of multicellular organismal process regulation of immune system process positive regulation of immune system process positive regulation of cellular process response to stimulus immune response cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process protein catabolic process macromolecule catabolic process protein metabolic process organic substance catabolic process multicellular organismal-level iron ion homeostasis multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis positive regulation of protein metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of metabolic process regulation of protein catabolic process response to metal ion response to iron ion response to chemical response to inorganic substance biological process involved in interspecies interaction between organisms response to other organism response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus localization cellular localization establishment of localization in cell establishment of localization homeostasis of number of cells myeloid cell homeostasis negative regulation of tissue remodeling negative regulation of bone remodeling regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption negative regulation of bone resorption tissue remodeling bone remodeling anatomical structure homeostasis negative regulation of multicellular organismal process system process regulation of intestinal absorption digestive system process negative regulation of intestinal absorption regulation of system process regulation of digestive system process digestion intestinal absorption negative regulation of digestive system process defense response to fungus response to fungus disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing transport monoatomic ion transmembrane transport iron ion transport iron ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport transition metal ion transport monoatomic ion transport monoatomic cation transport cellular response to stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway signaling cell communication signal transduction cell surface receptor signaling pathway via JAK-STAT negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of localization negative regulation of monoatomic ion transport negative regulation of iron ion transmembrane transport negative regulation of transport regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport regulation of iron ion transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport regulation of metal ion transport negative regulation of iron ion transport regulation of transport regulation of monoatomic ion transport regulation of iron ion transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport positive regulation of macromolecule biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	extracellular region cellular anatomical entity extracellular space membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010500	Hepcidin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P81172	hereditary hemochromatosis beta thalassemia hemochromatosis type 2B Wilson disease anemia biliary atresia chronic kidney disease Iron Overload hepatocellular carcinoma iron deficiency anemia large cell medulloblastoma primitive neuroectodermal tumor hemochromatosis type 1 iron metabolism disease kidney cancer hereditary hemochromatosis beta thalassemia hemochromatosis type 2B Wilson disease anemia biliary atresia chronic kidney disease Iron Overload hepatocellular carcinoma iron deficiency anemia large cell medulloblastoma primitive neuroectodermal tumor hemochromatosis type 1 iron metabolism disease kidney cancer X-linked mixed deafness with perilymphatic gusher cystic fibrosis glioblastoma hemochromatosis type 2 hereditary persistence of fetal hemoglobin inborn errors of metabolism kidney neoplasm atypical teratoid rhabdoid tumor medulloblastoma cholestasis thalassemia minor dilated cardiomyopathy hemochromatosis type 2A

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.