Annotations: 2JM6

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2jm6b2	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	EAT/MCL-1 (Myeloid cell leukemia sequence 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2jm6b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Bcl-2 inhibitors of programmed cell death	8030757	4002981	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Bcl-2-like inhibitors of programmed cell death	8043136	3001974	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00452	e2jm6B1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF15150	Phorbol-12-myristate-13-acetate-induced (PMAIP1)	Phorbol-12-myristate-13-acetate-induced	-	Family
B	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Noxa	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential regulation of catalytic activity positive regulation of protein metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of biological process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis metabolic process macromolecule metabolic process regulation of metabolic process regulation of cellular process signaling cell death intracellular signal transduction cell communication apoptotic signaling pathway signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death cellular metabolic process reactive oxygen species metabolic process signal transduction by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria cellular component organization positive regulation of release of cytochrome c from mitochondria cellular component organization or biogenesis positive regulation of cellular process mitochondrion organization regulation of organelle organization release of cytochrome c from mitochondria organelle organization regulation of mitochondrion organization cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process macromolecule catabolic process organic substance catabolic process response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process positive regulation of glucose metabolic process regulation of small molecule metabolic process small molecule metabolic process positive regulation of carbohydrate metabolic process positive regulation of small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process glucose metabolic process fibroblast apoptotic process positive regulation of cell communication extrinsic apoptotic signaling pathway via death domain receptors positive regulation of signal transduction regulation of signal transduction extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of signaling positive regulation of extrinsic apoptotic signaling pathway via death domain receptors cell surface receptor signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication regulation of apoptotic signaling pathway positive regulation of signaling positive regulation of fibroblast apoptotic process regulation of fibroblast apoptotic process regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator regulation of intracellular signal transduction regulation of response to stress regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of intracellular signal transduction signal transduction in response to DNA damage protein localization regulation of localization establishment of protein localization cellular localization regulation of protein localization positive regulation of establishment of protein localization localization cellular macromolecule localization regulation of establishment of protein localization establishment of localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of cellular localization macromolecule localization protein localization to organelle positive regulation of protein localization protein localization to mitochondrion establishment of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion intrinsic apoptotic signaling pathway in response to DNA damage response to light stimulus response to UV negative regulation of cell population proliferation fibroblast proliferation cell population proliferation negative regulation of biological process regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of fibroblast proliferation regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus membrane organization transport mitochondrial membrane organization regulation of membrane permeability regulation of mitochondrial membrane permeability mitochondrial transport response to organic substance response to chemical response to dsRNA response to nitrogen compound response to organic cyclic compound	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol protein-containing complex Bcl-2 family protein complex nucleus
B	Myeloid cell leukemia-1 protein Mcl-1 homolog	protein heterodimerization activity protein binding binding protein dimerization activity BH domain binding protein domain specific binding death domain binding BH3 domain binding identical protein binding protein homodimerization activity protein-containing complex binding passive transmembrane transporter activity channel activity transporter activity protein heterodimerization activity protein binding binding protein dimerization activity BH domain binding protein domain specific binding death domain binding BH3 domain binding identical protein binding protein homodimerization activity protein-containing complex binding passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of cellular process positive regulation of signal transduction regulation of oxidative stress-induced intrinsic apoptotic signaling pathway signaling positive regulation of biological process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of cellular process positive regulation of signal transduction regulation of oxidative stress-induced intrinsic apoptotic signaling pathway signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction intrinsic apoptotic signaling pathway positive regulation of neuron apoptotic process positive regulation of cellular process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of biological process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process biological regulation positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway regulation of response to stimulus positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of neuron apoptotic process regulation of apoptotic signaling pathway positive regulation of signaling developmental process cellular developmental process cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand negative regulation of signaling negative regulation of biological process negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process extrinsic apoptotic signaling pathway in absence of ligand cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway in absence of ligand organelle fusion cellular component organization organelle organization mitochondrial fusion cellular component organization or biogenesis mitochondrion organization regulation of anoikis negative regulation of anoikis anoikis response to organic substance response to chemical response to cytokine intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of cellular catabolic process negative regulation of catabolic process catabolic process cellular metabolic process negative regulation of metabolic process autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process metabolic process process utilizing autophagic mechanism regulation of metabolic process apoptotic mitochondrial changes release of cytochrome c from mitochondria	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane cytosol protein-containing complex Bcl-2 family protein complex nucleus membrane-enclosed lumen membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane cytosol protein-containing complex Bcl-2 family protein complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR024140	Phorbol-12-myristate-13-acetate-induced protein 1	Family
B	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
B	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
B	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
B	IPR002475	Bcl2-like	Family
B	IPR026298	Bcl-2 family	Family
B	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
B	IPR013281	Apoptosis regulator, Mcl-1	Family
B	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.