2JH9

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8090790	3000118	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8090791	3000118	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8090791	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Orbi_VP4_4th	e2jh9A4	A: alpha bundles	X: VP4 GT domain (From Topology)	H: VP4 GT domain (From Topology)	T: VP4 GT domain	F: Orbi_VP4_4th	ECOD (1.6)
A	Orbi_VP4_2nd	e2jh9A5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Orbi_VP4_2nd	ECOD (1.6)
A	Orbi_VP4_3rd	e2jh9A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Orbi_VP4_3rd	ECOD (1.6)
A	Orbi_VP4_1st	e2jh9A3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: VP4 N-terminal domain (From Topology)	T: VP4 N-terminal domain	F: Orbi_VP4_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)
A	1.20.1280.200	Mainly Alpha	Up-down Bundle	Monooxygenase	Orbivirus VP4 core protein, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05059	Orbivirus VP4 core protein (Orbi_VP4)	Orbivirus VP4 core protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	VP4 CORE PROTEIN	-	-	viral capsid icosahedral viral capsid virion component viral outer capsid

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043026	Orbivirus VP4 core, C-terminal	Homologous Superfamily
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR007753	Orbivirus VP4 core	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.