2I39

Crystal structure of Vaccinia virus N1L protein

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8052543	3001974	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8052543	3001974	SCOP2B (2022-06-29)
C	SCOP2 Family	VACV protein N1-like	8047916	4005875	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Bcl-2-like inhibitors of programmed cell death	8052543	3001974	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8052543	3001974	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8052543	3001974	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8052543	3001974	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06227	e2i39A1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)
B	PF06227	e2i39B1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)
C	PF06227	e2i39C1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)
D	PF06227	e2i39D1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)
E	PF06227	e2i39E1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)
F	PF06227	e2i39F1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06227	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)
B	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)
C	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)
D	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)
E	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)
F	1.10.437.20	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	dsDNA poxvirus	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF06227	Poxvirus Bcl-2-like proteins (Poxv_Bcl-2-like)	Poxvirus Bcl-2-like proteins	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Protein N1	-	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR022819	Poxvirus Bcl-2-like	Family
A, B, C, D, E A, B, C, D, E, F	IPR043018	Poxvirus domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR009353	Orthopoxvirus, Protein N1	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.