2HZE

Crystal structures of a poxviral glutaredoxin in the oxidized and reduced states show redox-correlated structural changes

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hzea1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Ectromelia virus Moscow ) [TaxId: 265874 ],	SCOPe (2.08)
A	d2hzea2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Ectromelia virus Moscow ) [TaxId: 265874 ],	SCOPe (2.08)
B	d2hzeb1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Ectromelia virus Moscow ) [TaxId: 265874 ],	SCOPe (2.08)
B	d2hzeb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Ectromelia virus Moscow ) [TaxId: 265874 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Thioltransferase	8075875	4000237	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8075876	3000031	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Thioredoxin-like	8075876	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glutaredoxin	e2hzeA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Glutaredoxin	ECOD (1.6)
B	Glutaredoxin	e2hzeB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Glutaredoxin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00462	Glutaredoxin (Glutaredoxin)	Glutaredoxin	-	Domain
B	PF00462	Glutaredoxin (Glutaredoxin)	Glutaredoxin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Glutaredoxin-1	-	-	virion component
B	Glutaredoxin-1	-	-	virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011899	Glutaredoxin, eukaryotic/virial	Domain
A	IPR011767	Glutaredoxin active site	Active Site
A	IPR014025	Glutaredoxin subgroup	Domain
A	IPR002109	Glutaredoxin	Domain
A	IPR047185	Glutaredoxin-1	Family
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
B	IPR011899	Glutaredoxin, eukaryotic/virial	Domain
B	IPR011767	Glutaredoxin active site	Active Site
B	IPR014025	Glutaredoxin subgroup	Domain
B	IPR002109	Glutaredoxin	Domain
B	IPR047185	Glutaredoxin-1	Family
B	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.