Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
C [auth X]Topoisom_I_Ce2h7fX2 A: alpha arraysX: HTHH: HTHT: DNA breaking-rejoining enzymesF: Topoisom_I_CECOD (1.6)
C [auth X]Topoisom_I_Ne2h7fX1 A: alpha arraysX: HTHH: HTHT: DNA breaking-rejoining enzymesF: Topoisom_I_NECOD (1.6)
C [auth X]VirDNA-topo-I_Ne2h7fX3 A: a+b two layersX: DNA topoisomerase I domain (From Topology)H: DNA topoisomerase I domain (From Topology)T: DNA topoisomerase I domainF: VirDNA-topo-I_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C [auth X]3.30.66.10 Alpha Beta 2-Layer Sandwich Viral Topoisomerase I DNA topoisomerase I domainCATH (4.3.0)
C [auth X]3.90.15.10 Alpha Beta Alpha-Beta Complex Topoisomerase I Chain A, domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth X]PF09266Viral DNA topoisomerase I, N-terminal (VirDNA-topo-I_N)Viral DNA topoisomerase I, N-terminalMembers of this family are predominantly found in viral DNA topoisomerase, and assume a beta(2)-alpha-beta-alpha-beta(2) fold, with a left-handed crossover between strands beta2 and beta3 [1].Domain
C [auth X]PF01028Eukaryotic DNA topoisomerase I, catalytic core (Topoisom_I)Eukaryotic DNA topoisomerase I, catalytic coreTopoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2].Domain

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
C [auth X]PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048