Annotations: 2GIY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2giya1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Alphaherpesvirus glycoprotein E	(Human alphaherpesvirus 1 strain KOS ) [TaxId: 10306 ],	SCOPe (2.08)
A	d2giya2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Human alphaherpesvirus 1 strain KOS ) [TaxId: 10306 ],	SCOPe (2.08)
B	d2giyb2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Alphaherpesvirus glycoprotein E	(Human alphaherpesvirus 1 strain KOS ) [TaxId: 10306 ],	SCOPe (2.08)
B	d2giyb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Human alphaherpesvirus 1 strain KOS ) [TaxId: 10306 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	V set domains-like	8054530	4007530	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054531	3000071	SCOP2 (2022-06-29)
B	SCOP2 Family	V set domains-like	8054532	4007530	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054533	3000071	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Herpes_gE	e2giyA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Herpes_gE	ECOD (1.6)
B	Herpes_gE	e2giyB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Herpes_gE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02480	Alphaherpesvirus glycoprotein E (Herpes_gE)	Alphaherpesvirus glycoprotein E	Glycoprotein E (gE) of Alphaherpesvirus forms a complex with glycoprotein I (gI) (Pfam:PF01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation [1]. This entry represe ...	Glycoprotein E (gE) of Alphaherpesvirus forms a complex with glycoprotein I (gI) (Pfam:PF01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation [1]. This entry represents the Ig-like domain of gE, identified as the Fc-binding domain [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Glycoprotein E	identical protein binding protein binding binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process	virion component viral membrane viral envelope membrane cellular anatomical entity virion membrane host cellular component host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell membrane host cell cytoplasm part host cell cytoplasm host cell part virion component viral membrane viral envelope membrane cellular anatomical entity virion membrane host cellular component host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell membrane host cell cytoplasm part host cell cytoplasm host cell part host cell endomembrane system host intracellular region host intracellular membrane-bounded organelle host intracellular organelle host cell endosome membrane host cell endosome host cell plasma membrane host cell junction anchoring junction cell junction cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR046463	Envelope glycoprotein E, N-terminal	Domain
A, B	IPR003404	Envelope glycoprotein E, Fc-binding domain	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR046463	Envelope glycoprotein E, N-terminal	Domain
A, B	IPR003404	Envelope glycoprotein E, Fc-binding domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.