2FSH
Complex SecA:AMP-PNP from Escherichia coli
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF07516 | e2fshA3 | A: alpha complex topology | X: Helical scaffold and wing domains of SecA (From Topology) | H: Helical scaffold and wing domains of SecA (From Topology) | T: Helical scaffold and wing domains of SecA | F: PF07516 | ECOD (1.6) |
A | PF07517 | e2fshA1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF07517 | ECOD (1.6) |
A | PF21090 | e2fshA2 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF21090 | ECOD (1.6) |
B | F_UNCLASSIFIED | e2fshB3 | A: alpha arrays | X: Pre-protein crosslinking domain of SecA (From Topology) | H: Pre-protein crosslinking domain of SecA (From Topology) | T: Pre-protein crosslinking domain of SecA | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF07516 | e2fshB2 | A: alpha complex topology | X: Helical scaffold and wing domains of SecA (From Topology) | H: Helical scaffold and wing domains of SecA (From Topology) | T: Helical scaffold and wing domains of SecA | F: PF07516 | ECOD (1.6) |
B | PF07517 | e2fshB1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF07517 | ECOD (1.6) |
B | PF21090 | e2fshB4 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF21090 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
B | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
B | 1.20.890.70 | Mainly Alpha | Up-down Bundle | cAMP-dependent Protein Kinase, Chain A | Protein translocase subunit SecA, preprotein binding domain | CATH (4.3.0) |
B | 1.10.3060.10 | Mainly Alpha | Orthogonal Bundle | Helical scaffold and wing domains of SecA | Helical scaffold and wing domains of SecA | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF07517 | SecA DEAD-like domain (SecA_DEAD) | SecA DEAD-like domain | SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner [1,2]. This do ... | Domain | |
PF07516 | SecA Wing and Scaffold domain (SecA_SW) | SecA Wing and Scaffold domain | - | Family | |
PF21090 | SecA P-loop domain (P-loop_SecA) | SecA P-loop domain | SecA is the preprotein translocase ATPase subunit and a superfamily 2 (SF2) RNA helicase [4]. This entry corresponds to the second P-loop domain. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR011130 | SecA, preprotein cross-linking domain | Domain | |
IPR011116 | SecA Wing/Scaffold | Domain | |
IPR014018 | SecA motor DEAD | Domain | |
IPR020937 | SecA conserved site | Conserved Site | |
IPR044722 | SecA, C-terminal helicase domain | Domain | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR036670 | SecA, preprotein cross-linking domain superfamily | Homologous Superfamily | |
IPR036266 | SecA, Wing/Scaffold superfamily | Homologous Superfamily | |
IPR001650 | Helicase, C-terminal domain-like | Domain | |
IPR000185 | Protein translocase subunit SecA | Family | |
IPR014001 | Helicase superfamily 1/2, ATP-binding domain | Domain | |
IPR004027 | SEC-C motif | Conserved Site | |
IPR011115 | SecA DEAD-like, N-terminal | Domain |