2FN5

NMR Structure of the Neurabin PDZ domain (502-594)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2fn5a1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	automated matches	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d2fn5a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e2fn5A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Neurabin-1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding identical protein binding protein domain specific binding GTPase binding transmembrane transporter binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding identical protein binding protein domain specific binding GTPase binding transmembrane transporter binding kinase binding protein kinase binding	negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication cellular process positive regulation of signaling regulation of cellular component organization regulation of synapse structural plasticity cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of localization cellular localization transport negative regulation of transport negative regulation of neurotransmitter transport regulation of spontaneous neurotransmitter secretion negative regulation of spontaneous neurotransmitter secretion localization regulation of secretion by cell secretion by cell negative regulation of secretion signal release establishment of localization in cell negative regulation of cellular process negative regulation of secretion by cell spontaneous synaptic transmission regulation of spontaneous synaptic transmission negative regulation of neurotransmitter secretion neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell neurotransmitter transport establishment of localization regulation of secretion spontaneous neurotransmitter secretion signal release from synapse regulation of neurotransmitter secretion multicellular organismal process regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development cell development regulation of dendritic spine development neuron projection development positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development system development developmental process dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development regulation of neuron projection development positive regulation of cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization regulation of cell projection organization regulation of plasma membrane bounded cell projection organization cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to toxic substance response to toxic substance cellular component biogenesis cellular component assembly cell junction assembly regulation of synapse assembly regulation of cellular component biogenesis regulation of cell junction assembly synapse assembly organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication positive regulation of long-term synaptic depression long-term synaptic depression regulation of long-term synaptic depression regulation of cytoskeleton organization regulation of actin filament-based process regulation of cellular component size regulation of protein-containing complex assembly protein-containing complex assembly regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization protein-containing complex organization regulation of actin polymerization or depolymerization regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization regulation of anatomical structure size cell projection morphogenesis neuron projection morphogenesis dendritic spine morphogenesis dendritic spine organization postsynapse organization regulation of postsynapse organization plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of anatomical structure morphogenesis dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis regulation of dendritic spine morphogenesis neuron projection organization postsynaptic cytoskeleton organization postsynaptic actin cytoskeleton organization regulation of actin filament bundle assembly actin filament bundle organization stress fiber assembly negative regulation of supramolecular fiber organization negative regulation of stress fiber assembly actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization negative regulation of actin filament bundle assembly regulation of stress fiber assembly negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly intracellular signal transduction calcium-mediated signaling intracellular signaling cassette signal transduction regulation of postsynaptic membrane potential system process chemical synaptic transmission, postsynaptic cell surface receptor signaling pathway nervous system process excitatory postsynaptic potential regulation of membrane potential filopodium assembly regulation of cell projection assembly regulation of filopodium assembly plasma membrane bounded cell projection assembly regulation of plasma membrane bounded cell projection assembly cell projection assembly	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle somatodendritic compartment dendrite cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle somatodendritic compartment dendrite dendritic tree neuron projection cytoplasm axon growth cone lamellipodium growth cone distal axon site of polarized growth synapse cell junction glutamatergic synapse neuromuscular junction neuron spine dendritic spine postsynapse cell body neuronal cell body dendritic spine neck actin-based cell projection filopodium postsynaptic cytoskeleton postsynaptic actin cytoskeleton cell cortex cortical cytoskeleton cell periphery cortical actin cytoskeleton postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001660	Sterile alpha motif domain	Domain
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR043446	Neurabin-like family	Family
A	IPR001478	PDZ domain	Domain
A	IPR040645	Neurabin-1/2, PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.