2DKQ
Solution structure of the PTB domain of KIAA1075 protein from human
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2dkqa1 | All beta proteins | PH domain-like barrel | PH domain-like | Phosphotyrosine-binding domain (PTB) | Tensin | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d2dkqa3 | Artifacts | Tags | Tags | Tags | C-terminal Tags | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d2dkqa2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.30.29.30 | Mainly Beta | Roll | PH-domain like | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08416 | Phosphotyrosine-binding domain (PTB) | Phosphotyrosine-binding domain | The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molec ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036860 | SH2 domain superfamily | Homologous Superfamily | |
IPR000980 | SH2 domain | Domain | |
IPR035012 | Tensin-like, SH2 domain | Domain | |
IPR029023 | Tensin-type phosphatase domain | Domain | |
IPR011993 | PH-like domain superfamily | Homologous Superfamily | |
IPR014020 | Tensin phosphatase, C2 domain | Domain | |
IPR033929 | Tensin, phosphotyrosine-binding domain | Domain | |
IPR006020 | PTB/PI domain | Domain | |
IPR029021 | Protein-tyrosine phosphatase-like | Homologous Superfamily | |
IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Domain | |
IPR013625 | Tensin/EPS8 phosphotyrosine-binding domain | Domain | |
IPR035892 | C2 domain superfamily | Homologous Superfamily | |
IPR046349 | C1-like domain superfamily | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
Q63HR2 | :