Annotations: 2CWO

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	P21 RNA silencing suppressor-like	8102732	3002744	SCOP2B (2022-06-29)
B	SCOP2 Family	P21 RNA silencing suppressor-like	8046527	4005126	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	P21 RNA silencing suppressor-like	8102732	3002744	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	P21 RNA silencing suppressor-like	8102732	3002744	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	P21 RNA silencing suppressor-like	8102732	3002744	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Suppressor_P21_C	e2cwoA2	A: alpha arrays	X: RNA silencing suppressor p21 C-terminal domain (From Topology)	H: RNA silencing suppressor p21 C-terminal domain (From Topology)	T: RNA silencing suppressor p21 C-terminal domain	F: Suppressor_P21_C	ECOD (1.6)
A	Suppressor_P21_N	e2cwoA1	A: alpha bundles	X: Spectrin repeat-like	H: RNA silencing suppressor p21 N-terminal domain (From Topology)	T: RNA silencing suppressor p21 N-terminal domain	F: Suppressor_P21_N	ECOD (1.6)
B	Suppressor_P21_C	e2cwoB1	A: alpha arrays	X: RNA silencing suppressor p21 C-terminal domain (From Topology)	H: RNA silencing suppressor p21 C-terminal domain (From Topology)	T: RNA silencing suppressor p21 C-terminal domain	F: Suppressor_P21_C	ECOD (1.6)
B	Suppressor_P21_N	e2cwoB2	A: alpha bundles	X: Spectrin repeat-like	H: RNA silencing suppressor p21 N-terminal domain (From Topology)	T: RNA silencing suppressor p21 N-terminal domain	F: Suppressor_P21_N	ECOD (1.6)
C	Suppressor_P21_C	e2cwoC1	A: alpha arrays	X: RNA silencing suppressor p21 C-terminal domain (From Topology)	H: RNA silencing suppressor p21 C-terminal domain (From Topology)	T: RNA silencing suppressor p21 C-terminal domain	F: Suppressor_P21_C	ECOD (1.6)
C	Suppressor_P21_N	e2cwoC2	A: alpha bundles	X: Spectrin repeat-like	H: RNA silencing suppressor p21 N-terminal domain (From Topology)	T: RNA silencing suppressor p21 N-terminal domain	F: Suppressor_P21_N	ECOD (1.6)
D	Suppressor_P21_C	e2cwoD1	A: alpha arrays	X: RNA silencing suppressor p21 C-terminal domain (From Topology)	H: RNA silencing suppressor p21 C-terminal domain (From Topology)	T: RNA silencing suppressor p21 C-terminal domain	F: Suppressor_P21_C	ECOD (1.6)
D	Suppressor_P21_N	e2cwoD2	A: alpha bundles	X: Spectrin repeat-like	H: RNA silencing suppressor p21 N-terminal domain (From Topology)	T: RNA silencing suppressor p21 N-terminal domain	F: Suppressor_P21_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.1200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.10.1200.170	Mainly Alpha	Orthogonal Bundle	Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein	Chain A	CATH (4.3.0)
B	1.20.58.1200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.10.1200.170	Mainly Alpha	Orthogonal Bundle	Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein	Chain A	CATH (4.3.0)
C	1.20.58.1200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.10.1200.170	Mainly Alpha	Orthogonal Bundle	Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein	Chain A	CATH (4.3.0)
D	1.20.58.1200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.10.1200.170	Mainly Alpha	Orthogonal Bundle	Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF11757	Suppressor of RNA silencing P21-like N-terminal domain (RSS_P20)	Suppressor of RNA silencing P21-like N-terminal domain	This domain can be found at the N-terminal region of is a large family of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of t ...	This domain can be found at the N-terminal region of is a large family of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of the major mechanisms of defence against viruses, and, in response, some viruses have evolved or acquired functions for suppression of RNA silencing. These counter-defencive viral proteins with RNA silencing suppressor (RSS) activity were originally discovered in the members of plant virus genera Potyvirus and Cucumovirus. Each of the conserved blocks of amino acids found in P21-like proteins corresponds to a computer-predicted alpha-helix, with the most C-terminal element being 42 residues long. This suggests conservation of the predominantly alpha-helical secondary structure in the P21-like proteins. C-terminal domain entry found under Pfam:PF11479.	Domain
A, B, C, D	PF11479	RNA silencing suppressor P21 C-terminal domain (Suppressor_P21)	RNA silencing suppressor P21 C-terminal domain	P21 is produced by Beet yellows virus to suppress the antiviral silencing response mounted by the host. P21 acts by binding directly to siRNA which is a mediator in the process. P21 has an octameric ring structure with a large central cavity [1]. Thi ...	P21 is produced by Beet yellows virus to suppress the antiviral silencing response mounted by the host. P21 acts by binding directly to siRNA which is a mediator in the process. P21 has an octameric ring structure with a large central cavity [1]. This is the C-terminal domain. The N-terminal domain is Pfam:PF11757.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	RNA silencing suppressor	RNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	-	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR021742	Suppressor of RNA silencing P21-like, N-terminal	Domain
A, B, C, D	IPR021575	RNA silencing suppressor P21, C-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.